三联降压药分时服用治疗反杓型高血压的临床观察

发布时间：2018-05-08 15:30

本文选题：左旋氨氯地平 + 替米沙坦　；参考：《中国药房》2017年15期

【摘要】：目的:观察左旋氨氯地平、替米沙坦联合氢氯噻嗪治疗反杓型高血压的疗效和安全性。方法:150例反杓型高血压患者随机分为A、B、C组,每组50例。A组患者给予替米沙坦片40 mg+氢氯噻嗪片10 mg,每日1次,清晨口服;B组患者给予左旋氨氯地平片5 mg,每日1次,晚间口服;C组患者给予替米沙坦片(用法用量同A组)+氢氯噻嗪片(用法用量同A组)+左旋氨氯地平片(用法用量同B组)。3组疗程均为8周。观察并比较3组患者治疗前后电解质水平、24 h动态血压变化情况及治疗后反杓型节律逆转为正常杓型节律的逆转率,记录不良反应发生情况。结果:3组患者治疗前后电解质水平比较,差异均无统计学意义(P0.05)。治疗前,3组患者24 h血压比较,差异均无统计学意义(P0.05);治疗后,3组患者24 h血压均显著低于同组治疗前,且C组均显著低于A组和B组,差异均有统计学意义(P0.05)。治疗后,C组反杓型节律逆转率显著高于A组和B组,差异均有统计学意义(P0.05)。3组患者不良反应发生率比较,差异均无统计学意义(P0.05)。结论:左旋氨氯地平、替米沙坦联合氢氯噻嗪分时服药治疗反杓型高血压不仅可以降低患者24 h血压,还能有效逆转反杓型节律,安全性亦较好。
[Abstract]:Aim: to observe the efficacy and safety of levamlodipine, telmisartan and hydrochlorothiazide in the treatment of antidipper hypertension. Methods one hundred and fifty patients with antidipper hypertension were randomly divided into group A (n = 50) and group A (n = 50) were given telmisartan 40 mg hydrochlorothiazide 10 mg once a day, and group B was given levamlodipine 5 mg once a day in the morning. Evening oral administration of telmisartan tablet (same dosage as group A) hydrochlorothiazide tablet (same dosage as group A) levamlodipine tablet (administration dosage same as group B) was used for 8 weeks. The changes of ambulatory blood pressure (ABBP) at 24 h before and after treatment and the reversal rate of anti-dipper rhythm to normal dipper rhythm were observed and compared before and after treatment, and the adverse reactions were recorded. Results there was no significant difference in electrolyte levels between the three groups before and after treatment (P 0.05). There was no significant difference in 24 h blood pressure between group C and group B before treatment, but the blood pressure of group C was significantly lower than that of group A and group B at 24 h after treatment, and the difference was statistically significant (P 0.05). After treatment, the reverse rate of anti-dipper rhythm in group C was significantly higher than that in group A and group B, and the difference was statistically significant. Conclusion: levamlodipine and telmisartan combined with hydrochlorothiazide in the treatment of antidipper hypertension can not only reduce the blood pressure of 24 hours, but also reverse the antidipper rhythm effectively.
【作者单位】：衡水市哈励逊国际和平医院老年病一科;
【基金】：衡水市科技计划自筹经费项目(No.2016014091Z)
【分类号】：R544.1

【相似文献】