非ST段抬高型急性冠脉综合征患者MLR变化及其与冠脉病变程度的关系

发布时间：2018-05-08 15:58

本文选题：非ST段抬高急性冠脉综合征 + 单核细胞与淋巴细胞比值　；参考：《山东医药》2017年28期

【摘要】：目的探讨非ST段抬高型急性冠脉综合征(NSTE-ACS)患者单核细胞与淋巴细胞比值(MLR)变化及其与冠脉病变程度的关系。方法选择NSTE-ACS患者319例,根据SYNTAX评分将患者分为轻度病变组152例、中度病变组89例、重度病变组78例,另选非冠心病患者237例(非冠心病组),采集各组外周静脉血进行单核细胞和淋巴细胞计数,计算MLR。采用受试者工作特征(ROC)曲线评价MLR诊断NSTE-ACS的价值。采用线性回归方程分析MLR与NSTE-ACS冠脉病变程度的关系。结果轻度病变组、中度病变组、重度病变组MLR均高于对照组,且随着冠脉病变程度加重,MLR逐渐升高(P均0.01)。ROC曲线分析显示,MLR诊断NSTE-ACS的曲线下面积为0.712(95%CI:0.636~0.752),诊断临界值为0.23,此时其诊断NSTE-ACS的敏感性为68.15%、特异性为63.89%。线性回归方程分析显示,MLR与SYNTAX评分呈正相关关系(r=0.54,P0.01)。结论 NSTE-ACS患者MLR水平升高,且其水平变化与冠脉病变程度有关。
[Abstract]:Objective to investigate the changes of monocyte / lymphocyte ratio (MLR) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACSC) and its relationship with the severity of coronary artery disease. Methods according to SYNTAX score, 319 patients with NSTE-ACS were divided into mild lesion group (n = 152), moderate lesion group (n = 89) and severe lesion group (n = 78). Another 237 patients (non-coronary heart disease group) were selected. Peripheral venous blood was collected to count monocytes and lymphocytes in each group, and MLR was calculated. The value of MLR in the diagnosis of NSTE-ACS was evaluated by using the operating characteristics of subjects. The relationship between MLR and the severity of coronary artery lesion in NSTE-ACS was analyzed by linear regression equation. Results the MLR of mild lesion group, moderate lesion group and severe lesion group were higher than that of control group. The area under the curve of MLR was 0.712 ~ 95% CI: 0.636 ~ 0.752g, and the critical value was 0.23. At this time, the sensitivity of NSTE-ACS was 68.15 and the specificity was 63.89. Linear regression equation analysis showed that there was a positive correlation between MLR and SYNTAX score. Conclusion the level of MLR in NSTE-ACS patients is increased, and the change of MLR level is related to the severity of coronary artery disease.
【作者单位】：民航总医院北京大学民航临床医学院;
【分类号】：R541.4

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