H型高血压与血管内皮功能和主动脉顺应性的相关性

发布时间：2018-05-08 21:15

本文选题：H型高血压 + 血管内皮功能　；参考：《广东医学》2017年13期

【摘要】：目的探讨在同等血压条件下,H型高血压患者与非H型高血压患者血管内皮功能和血管顺应性的差异。方法入选H型高血压患者(H型组)、非H型高血压患者(非H型组)及正常血压者(对照组)各120例,测定肱动脉血流介导血管舒张功能(FMD)、主动脉顺应性指数,同时测定血浆同型半胱氨酸(Hcy)水平,分析H型高血压与血管内皮功能和主动脉顺应性的相关性,并进一步分析Hcy升高是否为H型高血压患者血管内皮功能和主动脉顺应性受损的独立危险因素。结果 H型组与对照组相比,FMD减小,主动脉张力及主动脉膨胀指数降低,主动脉僵硬指数增高,组间差异有统计学意义(P0.05)。H型高血压与FMD、主动脉顺应性有很高的相关性。且Hcy升高是H型高血压患者血管内皮功能和主动脉顺应性受损的独立危险因素。结论高血压患者血管内皮功能和主动脉顺应性受损与Hcy存在一定程度相关性,Hcy是高血压患者血管内皮功能和主动脉顺应性受损的一个早期预测因子。
[Abstract]:Objective to investigate the differences in vascular endothelial function and vascular compliance in patients with type H hypertension and non H type hypertension under the same blood pressure. Methods 120 patients with H type hypertension (H type), non H hypertensive patients (non H group) and normal blood pressure (control group) each were selected to determine the brachial artery blood flow mediated vasodilatation (FMD), and the activity of vascular vasodilatation (FMD) was measured. The plasma homocysteine (Hcy) level was measured and the correlation between H type hypertension and vascular endothelial function and aortic compliance was analyzed. The independent risk factors for vascular endothelial function and aortic compliance damage in patients with H type hypertension were further analyzed. Results the H group was compared with the control group, FMD Decreased aortic tension and aortic dilation index and increased aortic stiffness index, there was a significant difference between the groups (P0.05).H type hypertension and FMD, and the aortic compliance was highly correlated. And the elevation of Hcy was an independent risk factor for vascular endothelial function and damage of aortic compliance in patients with H type hypertension. Conclusion hypertension patients The damage of vascular endothelial function and aortic compliance is related to Hcy to a certain extent. Hcy is an early predictor of vascular endothelial function and aortic compliance damage in patients with hypertension.

【作者单位】：佛山市顺德区第一人民医院附属杏坛医院内一科;
【基金】：广东省医学科学技术研究基金资助项目(编号:A2015237)
【分类号】：R544.1

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