有氧运动时程对2K1C肾血管高血压大鼠心血管及肾脏功能的影响

发布时间：2018-05-19 11:05

本文选题：有氧运动 + 两肾一夹型高血压大鼠　；参考：《中国病理生理杂志》2017年08期

【摘要】：目的:探究有氧运动(aerobic exercise,AE)的时程对两肾一夹型(2K1C)高血压大鼠平均动脉压(mean arterial pressure,MAP)、窦性心动过缓、心脏和肾脏组织学以及氧化损伤的影响,从而评估AE改善高血压状况的具体效果。方法:选取健康雄性Wistar大鼠60只,随机分为假手术(sham)组和2K1C组,手术后将两组大鼠分别分为sham安静(sham+SED)组、sham运动(sham+AE)组、2K1C安静(2K1C+SED)组及2K1C运动(2K1C+AE)组。sham+AE组和2K1C+AE组的大鼠进行AE,AE的方式为每天游泳1次,每次游泳1 h,一共持续运动10周。定期检测4组大鼠的MAP、窦性心动过缓改善情况以及心脏和肾脏组织学的变化等。结果:第4周时发现,2K1C+AE组大鼠的MAP和窦性心动过缓得到了明显的改善,心肌和肾脏中胶原沉积相对于2K1C+SED组明显减少,左心室中硫代巴比妥酸反应物(TBARS)的水平也明显降低,且左心室和肾脏过氧化氢酶(CAT)的活性较2K1C+SED组也显著升高。但第6周至第10周的结果显示,2K1C+AE组与2K1C+SED组之间大鼠MAP和窦性心动过缓的差异逐渐缩小。第8周时2K1C+AE组大鼠左心室和肾脏中TBARS的水平以及双肾中CAT的活性部分恢复。第10周时2K1C+AE组大鼠心脏和双肾中胶原沉积降低到最低水平。结论:适度(约4周)AE能有效改善2K1C肾血管高血压大鼠MAP和窦性心动过缓,并且可以通过调控氧化应激反应,减轻高血压所致的心脏及肾脏损伤。
[Abstract]:Objective: to investigate the effects of aerobic exercise on mean arterial pressure MAPP, sinus bradycardia, heart and kidney histology and oxidative injury in two kidney and one clip hypertension rats. Methods: sixty healthy male Wistar rats were randomly divided into sham group and 2K1C group. After operation, the two groups of rats were divided into two groups: sham exercise group (2K1C + 2K1C SED) group and 2K1C exercise group (2K1C) group. Sham AE group and 2K1C AE group (2K1C AE group) were swimming once a day for 1 hour each time for a total of 10 weeks of continuous exercise. MAPP, improvement of sinus bradycardia and histological changes of heart and kidney were detected regularly in 4 groups. Results: at the 4th week, MAP and sinus bradycardia were significantly improved, collagen deposition in myocardium and kidney was significantly decreased compared with that in 2K1C SED group, and the level of thiobarbituric acid (TBA) in left ventricle was also significantly decreased. The activity of catalase in left ventricle and kidney was significantly higher than that in 2K1C SED group. However, the results from week 6 to week 10 showed that the difference of MAP and sinus bradycardia between the two groups was gradually reduced. At 8 weeks, the level of TBARS in left ventricle and kidney and the activity of CAT in both kidneys were partially recovered in 2K1C AE group. At the 10th week, collagen deposition in heart and kidney of 2K1C AE group was reduced to the lowest level. Conclusion: moderate (about 4 weeks) AE can effectively improve MAP and sinus bradycardia in 2K1C rats with renal vascular hypertension, and can alleviate the heart and kidney damage induced by hypertension by regulating oxidative stress response.
【作者单位】：通辽职业学院基础医学部;
【基金】：内蒙古自然科学基金资助项目(No.201307010901) 内蒙古自治区高职教育研究立项课题(No.TZYKT13006)
【分类号】：R544.1

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