甲状腺功能与心房颤动相关性的研究

发布时间：2018-05-19 18:24

本文选题：甲状腺激素 + 甲状腺功能　；参考：《重庆医科大学》2017年硕士论文

【摘要】：心房纤颤动是常见的心律失常之一,甲状腺功能状态与房颤息息相关。心脏是甲状腺激素重要的靶器官之一,甲状腺激素能够通过其基因效应及非基因效应调控心脏的结构及功能。异常的甲状腺功能改变其生理性效应,从而影响心脏的结构功能,可促进房颤的发生及维持。大型临床试验研究显示甲状腺功能亢进患者更容易发生心房颤动,甲亢动物模型的房颤可诱导性及持续性均明显增加,表明甲亢是房颤的高危因素。就目前已有研究显示,甲状腺功能减退是否增加额外的房颤风险仍存在争议,但在接受心脏手术的患者中,甲状腺功能减退可增加术后发生房颤的风险。房颤可引起致残、致死性脑血管意外,而甲状腺功能状态可影响机体凝血功能,从而改变房颤患者栓塞风险,在诊疗活动更为强调保持正常的甲状腺功能水平。
[Abstract]:Atrial fibrillation is one of the common arrhythmias. Thyroid function is closely related to atrial fibrillation. The heart is one of the important target organs of thyroid hormone. Thyroid hormone can regulate the structure and function of heart through its gene effect and non-gene effect. Abnormal thyroid function changes its physiological effect, thus affecting the cardiac structure and function, which can promote the occurrence and maintenance of atrial fibrillation. Large clinical trials showed that patients with hyperthyroidism were more likely to develop atrial fibrillation, and the induced and persistent atrial fibrillation in hyperthyroidism animal model were significantly increased, indicating that hyperthyroidism was a high risk factor for atrial fibrillation. Whether hypothyroidism increases the risk of atrial fibrillation remains controversial, but in patients undergoing cardiac surgery, hypothyroidism may increase the risk of postoperative AF. Atrial fibrillation can cause disability, fatal cerebrovascular accident, and thyroid function can affect the coagulation function of the body, thus changing the risk of embolism in patients with atrial fibrillation, and more emphasis on maintaining normal thyroid function level in diagnosis and treatment activities.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.75

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