青年高血压患者注意功能事件相关电位的研究

发布时间：2018-05-26 02:22

本文选题：青年 + 高血压　；参考：《临床神经病学杂志》2017年01期

【摘要】：目的探讨青年高血压患者视觉注意功能障碍的特点及神经机制。方法采用Oddball范式对24例原发性青年高血压患者(高血压组)和23例正常对照者(正常对照组)的事件相关电位(ERP)成分进行检测,并对所有受试者采用MMSE进行认知功能评估。结果高血压组MMSE评分显著低于正常对照组(t=-10.36,P0.05)。N2平均波幅电极位之间主效应有显著性差异(P0.01),表现为显著的额区分布。高血压组P3a及P3b的平均波幅较正常对照组显著减小(均P0.05)。高血压组顶区PZ P3a波幅较正常对照组波幅显著下降(P0.05),两组间前额部FZ及中央区CZ差异无统计学意义。高血压组与正常对照组间P3a、P3b各位置潜伏期差异均无统计学意义。MMSE评分与P3b波幅呈正相关(r=0.61,P=0.05),与P3a波幅无关(r=0.19,P0.05)。结论青年高血压患者视觉注意已经受到损害,视觉P300可作为早期识别青年高血压患者存在的注意功能损害的客观指标。
[Abstract]:Objective to investigate the characteristics and neural mechanism of visual attention disorder in young hypertensive patients. Methods the components of event-related potentials (ERP) in 24 young patients with essential hypertension (EH group) and 23 normal controls (normal control group) were measured by Oddball paradigm. The cognitive function of all subjects was evaluated with MMSE. Results the MMSE score of hypertension group was significantly lower than that of normal control group (P 0.05N _ 2, P 0.05N _ 2). There was a significant difference in the main effect between the electrode sites of the mean amplitude of N _ 2 and the mean amplitude of P _ (0.01), showing a significant frontal area distribution. The average amplitude of P3a and P3b in hypertension group was significantly lower than that in normal control group (P 0.05). The amplitude of PZ P3a in the parietal region of hypertension group was significantly lower than that in the normal control group (P 0.05), but there was no significant difference between the two groups in the FZ of the prefrontal region and CZ in the central region. There was no significant difference in the latency of P3a and P3b between the hypertension group and the normal control group. MMSE score was positively correlated with the P3b amplitude, but not with the P3a amplitude. Conclusion the visual attention of young patients with hypertension has been impaired, and visual P300 can be used as an objective index to identify the impairment of attention function in young patients with hypertension.
【作者单位】：济宁市第一人民医院神经内科;
【基金】：山东省科学发展计划(2008GG30002058)
【分类号】：R544.1

【相似文献】