老年汉族人群KL基因G-395A多态性与冠状动脉粥样硬化性心脏病及胱抑素C水平的相关性分析

发布时间：2018-05-27 07:08

本文选题：Klotho基因 + 多态性　；参考：《重庆医学》2017年23期

【摘要】：目的研究华中地区老年汉族人群Klotho(KL)基因的G-395A位点多态性与冠状动脉粥样硬化性心脏病(以下简称冠心病)及胱抑素C(Cys-C)水平的相关性。方法选取该院老年科(年龄大于或等于60岁)汉族冠心病患者138例(冠心病组),无冠心病老年人140例(对照组)作为研究对象,用TaqMan基因探针法分别检测两组KL基因G-395A位点的基因型,并分析该位点基因多态性与冠心病及血清Cys-C水平的相关性。结果与对照组相比,冠心病组KL基因的G-395A位点GG基因型频率明显增高(P0.05),AA基因型和AG基因型的频率差异无统计学意义(P0.05)。无论在对照组还是冠心病组,GG基因型的人Cys-C水平均高于AA和AG基因型。结论在华中地区老年汉族人群中,KL基因的G-395A位点为GG基因型的人患冠心病的风险较高。KL基因G-395A位点的基因突变可能通过影响血Cys-C水平,抑制动脉粥样硬化的发生发展。
[Abstract]:Objective to study the relationship between G-395A locus polymorphism of Klothosil gene and the levels of coronary atherosclerotic heart disease (CHD) and cystatin Cys-Cin in the elderly Han population in central China. Methods 138 patients with coronary heart disease (CHD group) and 140 elderly patients without coronary heart disease (control group) in the geriatrics department (age > or equal to 60 years old) were selected as the study objects. The genotypes of G-395A locus of KL gene in two groups were detected by TaqMan gene probe method. The relationship between the polymorphism of G-395A locus and coronary heart disease (CHD) and serum Cys-C level was analyzed. Results compared with the control group, the frequency of G-395A GG genotype of KL gene in CHD group was significantly higher than that of P0.05A genotype and AG genotype. The level of Cys-C in GG genotype was higher than that in AA and AG genotype in both control group and coronary heart disease group. Conclusion in the elderly Han population in central China, the risk of coronary heart disease is higher in those with G-395A GG genotype of KL gene. The mutation of G-395A locus of KL gene may inhibit the occurrence and development of atherosclerosis by affecting the level of serum Cys-C.
【作者单位】：湖北省武汉市中心医院老年科;
【基金】：湖北省武汉市科技局资助课题(201260523187-4) 湖北省武汉市卫生和计划生育委员会科研计划资助项目(WX12C04)
【分类号】：R541.4

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