老年不稳定型心绞痛患者外周血内脏脂肪素水平的改变及意义

发布时间：2018-05-27 10:45

本文选题：不稳定型心绞痛 + 内脏脂肪素　；参考：《中国老年学杂志》2017年10期

【摘要】：目的观察内脏脂肪素在老年不稳定型心绞痛(UA)外周血水平的变化,探讨其与炎症因子及相关黏附分子之间的相关性。方法比较UA患者44例(观察组)及稳定型心绞痛(SA)42例(对照组)两组血脂指标、内脏脂肪素、炎症性因子、可溶性血管细胞间黏附分子(sVCAM)-1、可溶性细胞间黏附分子(sICAM)-1水平;并采用Pearson相关检验对内脏脂肪素与肿瘤坏死因子(TNF)-α、sVCAM-1、sICAM-1进行相关性分析。结果两组血脂指标总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、白细胞介素(IL)-10水平无显著差异(均P0.05);观察组内脏脂肪素、VCAM-1、sICAM-1、TNF-α水平显著高于对照组(P0.05);相关性分析显示UA患者内脏脂肪素水平与TNF-α(r=0.693,P0.01)、sVCAM-1(r=0.722,P0.01)及sICAM-1(r=0.708,P0.01)呈正相关。结论 UA患者体内内脏脂肪素水平比SA患者高,并且与TNF-α、VCAM-1、sICAM-1呈正相关,说明内脏脂肪素与血管内皮损伤有关,可作为预测不稳定斑块的指标。
[Abstract]:Objective to observe the changes of visceral fat in the peripheral blood of elderly patients with unstable angina pectoris (UAA) and to explore the relationship between visceral adipotin and inflammatory factors and adhesion molecules. Methods 44 patients with UA (observation group) and 42 patients with stable angina pectoris (control group) were divided into two groups: lipid index, visceral adipoxin, inflammatory factor, soluble vascular intercellular adhesion molecule (sVCAM-1) and soluble intercellular adhesion molecule (sICAM-1). Pearson correlation test was used to analyze the correlation between visceral adipotin and tumor necrosis factor TNF- 伪 -VCAM-1 and sICAM-1. Results there was no significant difference between the two groups in the levels of TC, TG, HDL-CU, LDL-CU and IL-IL-10 (all P 0.05), and the levels of visceral adipotin (VCAM-1) and sICAM-1TNF- 伪 in the observation group were significantly higher than those in the control group (P < 0.05), and the levels of VCAM-1sICAM-1TNF- 伪 in the observation group were significantly higher than those in the control group. The correlation analysis showed that the level of visceral fat in UA patients was positively correlated with the levels of TNF- 伪, TNF- 伪, 0.693and sVCAM-1, 0.722, P0.01, and sICAM-1, 0.708, P0.01, respectively. Conclusion the level of visceral adipose in UA patients is higher than that in SA patients, and it is positively correlated with TNF- 伪 VCAM-1sICAM-1, which indicates that visceral adipotin is related to vascular endothelial injury and can be used as a predictor of unstable plaque.
【作者单位】：三亚市人民医院老年病科;
【分类号】：R541.4

【相似文献】