急性冠脉综合征临界病变血清尿酸及其对PCI预后的影响

发布时间：2018-05-28 03:47

本文选题：急性冠脉综合征 + 尿酸　；参考：《实用医学杂志》2017年04期

【摘要】：目的:探讨血清尿酸(SUA)水平与急性冠脉综合征(ACS)临界病变患者冠脉病变程度的相关性及其对冠脉介入治疗(PCI)预后的影响。方法:将192例诊断为ACS临界病变和PCI术的患者分为高尿酸组和正常尿酸组,比较两组间冠脉狭窄程度、PCI术中的冠脉血流情况及主要不良心血管事件(MACE)的发生率。结果:尿酸与Gensini积分呈正相关(r=0.710,P0.05)。高尿酸组PCI术中无复流、住院期间和术后6个月MACE的发生率明显高于正常尿酸组(P0.05)。尿酸与PCI术后无复流、住院期间MACE独立相关(P0.05)。结论:ACS临界病变患者尿酸水平越高,冠脉狭窄程度越重,发生冠脉无复流的风险增加。
[Abstract]:Objective: to investigate the correlation between serum uric acid (UAA) level and the severity of coronary artery disease in patients with acute coronary syndrome (ACS) critical lesion and its influence on the prognosis of coronary intervention therapy (PCI). Methods: 192 patients diagnosed as ACS critical lesion and PCI were divided into high uric acid group and normal uric acid group. The coronary blood flow and the incidence of major adverse cardiovascular events during coronary stenosis were compared between the two groups. Results: there was a positive correlation between uric acid and Gensini score. There was no reflow during PCI in high uric acid group, and the incidence of MACE during hospitalization and 6 months after operation was significantly higher than that in normal uric acid group (P 0.05). There was no reflow between uric acid and PCI, and MACE was independently correlated with P0.05 during hospitalization. Conclusion the higher the uric acid level in the patients with critical disease of ACS, the more severe the coronary stenosis and the higher the risk of no reflow.
【作者单位】：成都医学院第一附属医院心血管内科衰老与血管稳态四川省高校重点实验室;
【基金】：国家自然科学基金项目(编号:81400289) 四川省科技厅应用基础研究计划项目(编号:2015JY0275);四川省科技厅科技创新苗子工程(编号:2016070) 四川省科技计划青年基金项目(编号:2016JQ0032) 四川省卫生计生委科研项目(编号:150047) 四川省教育厅自然科学重点项目(编号:16ZA0277) 北京力生心血管健康基金会领航基金项目(编号:LHJJ20157620)
【分类号】：R541.4

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