血清Periostin、VEGF及ET-1水平对高血压患者颈动脉病变和心血管事件的预测价值

发布时间：2018-06-01 21:54

本文选题：骨膜蛋白 + 血管内皮生长因子　；参考：《重庆医学》2017年18期

【摘要】：目的探讨血清骨膜蛋白(Periostin)、血管内皮生长因子(vascular endothelial growth factor,VEGF)及内皮素-1(ET-1)水平对高血压患者颈动脉病变和心脑血管事件的预测价值。方法选取2012年6月至2015年6月在该院住院治疗的原发性高血压(EH)患者150例,根据颈动脉内膜厚度将其分为颈动脉内膜正常组(A组,n=39)、颈动脉内膜增厚组(B组,n=67)和颈动脉斑块组(C组,n=44)。采用酶联免疫吸附测定(ELISA)法检测血清中Periostin、VEGF及ET-1水平,所有患者均进行颈动脉彩色超声评价动脉粥样硬化情况,随访至2016年9月,记录患者心脑血管事件情况,Logistic回归分析Periostin、VEGF及ET-1水平与颈动脉粥样硬化及心脑血管事件的关系。结果 C组患者Periostin、VEGF、ET-1水平分别为(183.54±51.43)mg/L、(201.87±6.54)mg/L、(4.43±0.76)ng/L,明显高于A、B组患者;且随着颈动脉病变的加重,Periostin、VEGF、ET-1水平逐渐升高(P0.05)。Logistic回顾模型,单因素分析显示平均动脉压(MAP)、Periostin、VEGF、ET-1与EH患者心脑血管事件密切相关(P0.05);多因素分析显示(MAP)、Periostin、VEGF、ET-1是EH心脑血管事件的独立危险因素(P0.05)。结论 Periostin、VEGF、ET-1水平随着冠状动脉病变严重程度的增加而升高,Periostin、VEGF、ET-1是急性冠状动脉综合征患者死亡的独立预测风险因素。
[Abstract]:Objective to investigate the predictive value of serum periosteal protein (Periostin), vascular endothelial growth factor (endothelial growth) and endothelin-1 (ET-1) for carotid artery disease and cardiovascular and cerebrovascular events in patients with hypertension. Methods from June 2012 to June 2015, 150 patients with essential hypertension (EH) who were hospitalized in our hospital were selected. According to the intimal thickness of carotid artery, it was divided into two groups: group A (normal carotid intima), group A (n = 39), group B (n = 67) and group C (n = 44). Serum levels of Periostinia VEGF and ET-1 were measured by Elisa. All patients were evaluated by carotid color ultrasound and followed up until September 2016. To record the cardiovascular events and logistic regression analysis of the relationship between the levels of ET-1 and carotid atherosclerosis and cardiovascular and cerebrovascular events. Results the level of VEGF ET-1 in group C was 183.54 卤51.43 mg / L respectively, which was significantly higher than that in group A (4.43 卤0.76 mg / L). Univariate analysis showed that the mean arterial pressure MAPP / VEGF et 1 was closely related to cardiovascular and cerebrovascular events in EH patients (P 0.05), and the multivariate analysis showed that MAPP was an independent risk factor for cardiovascular and cerebrovascular events in EH patients (P 0.05). Conclusion Periostin VEGF ET-1 level increases with the severity of coronary artery disease and is an independent predictor of death in patients with acute coronary syndrome.
【作者单位】：山东医学高等专科学校附属医院检验科;
【分类号】：R544.1

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