原发性高血压与血尿酸的相关性研究

发布时间：2018-06-03 09:59

本文选题：原发性高血压 + 血清尿酸　；参考：《西安医学院》2017年硕士论文

【摘要】：目的初步了解原发性高血压患者中血尿酸的水平及高尿酸血症的患病率,探讨血尿酸水平与原发性高血压患者血压分级及危险分层的相关性,希望能对临床上原发性高血压的早期防治、病情评估和治疗预后有所帮助,以及为后续的血尿酸与原发性高血压的深入研究提供参考。方法依据严格的入选标准随机收取2016年1月-2016年12月于西安市西安医学院第二附属医院就诊的高血压患者(研究组)138例,其中男性59例,女性79例,依据血压水平分为1级高血压组69例、2级高血压组37例、3级高血压组32例。再依据危险分层分为低危组39例、中危组33例、高危组32例、很高危组34例。另选取同期参加体检的健康患者(对照组)61例,其中男24例,女37例。分别测定各组血清尿酸水平及高尿酸血症患病率,分析血清尿酸水平是否与原发性高血压具有一定的相关性。结果1、高血压组血尿酸的水平为317.41±106.91 umol/L,明显高于对照组223.64±62.69umol/L的尿酸水平,p0.05,其高血压组高尿酸血症的患病率为18.1%,亦明显高于对照组3.3%的高尿酸血症的患病率,p0.05。高血压组男性血尿酸水平为363.12±113.28 umol/L,女性284.01±88.84 umol/L,分别高于对照组249.04±73.96 umol/L及207.16±48.44 umol/L的尿酸水平,p0.05。无论高血压组还是对照组,血尿酸水平均为男性高于女性,p0.05。2、3级高血压组血尿酸水平424.22±94.24 umol/L,高尿酸血症的患病率34.4%,2级高血压组血尿酸水平332.84±76.53 umol/L,高尿酸血症的患病率为21.6%,1级高血压组血尿酸水平259.59±83.59 umol/L,高尿酸血症的患病率为8.7%,3组之间血尿酸水平及高尿酸血症的患病率均有显著性差异,p0.05。3、高血压很高危组血尿酸的水平为423.85±82.48 umol/L,高尿酸血症的患病率为32.4%,高危组血尿酸的水平为360.91±75.71 umol/L,高尿酸血症的患病率21.9%,中危组血尿酸的水平为288.58±61.56 umol/L,高尿酸血症的患病率为12.1%,低危组血尿酸的水平为213.31±62.10 umol/L,高尿酸血症的患病率为7.7%,4组之间血尿酸水平及高尿酸血症的患病率均有显著性差异,p0.05。结论1、原发性高血压患者存在血尿酸水平及高尿酸血症患病率明显升高的表现,且男性血尿酸水平显著高于女性。2、原发性高血压患者血压分级越高,其血尿酸水平及高尿酸血症患病率越高,反之,血压分级越低,血尿酸水平及高尿酸血症患病率越低。3、原发性高血压患者危险分层越高,其血尿酸水平及高尿酸血症患病率越高,反之,危险分层越低,血尿酸水平及高尿酸血症患病率越低。4、血尿酸水平升高与原发性高血压密切相关,是高血压的危险因素之一,其可能参与高血压的致病、进程及预后,在临床检测中具有重要的应用价值,可为疾病的早期防治、病情评估和治疗预后提供重要参考。
[Abstract]:Objective to investigate the level of serum uric acid and the prevalence of hyperuricemia in patients with essential hypertension, and to explore the correlation between serum uric acid levels and blood pressure grading and risk stratification in patients with essential hypertension. It is hoped that it will be helpful to the early prevention and treatment of primary hypertension in clinic, to the evaluation of the condition and the prognosis of treatment, and to the further study of serum uric acid and essential hypertension. Methods according to strict selection criteria, 138 hypertensive patients (59 males and 79 females) who were admitted to the second affiliated Hospital of Xi'an Medical College in Xi'an City from January 2016 to December 2016 were randomly selected. According to blood pressure level, there were 69 cases of grade 1 hypertension group and 37 cases of grade 3 hypertension group. According to the risk stratification, 39 cases were divided into low risk group, 33 middle risk group, 32 high risk group and 34 very high risk group. In addition, 61 healthy patients (control group, 24 males and 37 females) were selected. The serum uric acid level and the prevalence rate of hyperuricemia were measured, and the correlation between serum uric acid level and essential hypertension was analyzed. Results 1 the level of serum uric acid in hypertension group was 317.41 卤106.91 umol/ L, which was significantly higher than that in control group (223.64 卤62.69umol/L) (p 0.05). The prevalence of hyperuricemia in hypertension group was 18.1% and significantly higher than that in control group (3.3%). The serum uric acid levels in the hypertension group were 363.12 卤113.28 umol/ L and 284.01 卤88.84 umol / L, respectively, which were higher than those in the control group at 249.04 卤73.96 umol/L and 207.16 卤48.44 umol/L, respectively. Whether the hypertension group or the control group, The levels of serum uric acid in males were higher than those in females in grade 3 hypertension group (424.22 卤94.24 umol / L), the prevalence rate of hyperuricemia was 332.84 卤76.53 umol/ L in grade 2 hypertension group, and the prevalence rate of hyperuricemia group was 259.59 卤83.59 in grade 1 hypertension group. Umolr / L, the prevalence of hyperuricemia was 8.7U / L and the prevalence of hyperuricemia was significantly different among the three groups (p 0.05.3). The level of serum uric acid in the high risk group was 423.85 卤82.48 umol / L, the prevalence rate of hyperuricemia was 32.4%, and the prevalence rate of hyperuricemia was 32.4b in the high risk group. The level of acid was 360.91 卤75.71 umol/ L, the prevalence rate of hyperuricemia was 21.9, the level of serum uric acid in moderate risk group was 288.58 卤61.56 umolr / L, the prevalence rate of hyperuricemia was 12.1umol / L, the level of serum uric acid in low-risk group was 213.31 卤62.10 umol/ L, and the prevalence rate of hyperuricemia was 7.7U / L among the four groups. There was a significant difference between the prevalence rate of ping and hyperuricemia (P 0.05). Conclusion 1. The serum uric acid level and the prevalence rate of hyperuricemia in patients with essential hypertension were significantly higher than those in women. The higher the blood pressure grade was in patients with essential hypertension, the higher the level of serum uric acid was. The higher the level of serum uric acid and the prevalence of hyperuricemia, the lower the blood pressure grade, the lower the serum uric acid level and the prevalence rate of hyperuricemia, the higher the risk stratification of essential hypertension. The higher the level of serum uric acid and the prevalence of hyperuricemia, the lower the risk stratification, the lower the prevalence rate of serum uric acid and hyperuricemia, and the higher the level of serum uric acid is associated with essential hypertension, which is one of the risk factors of hypertension. It may be involved in the pathogenesis, progression and prognosis of hypertension. It has important application value in clinical detection, and can provide important reference for early prevention, treatment and prognosis of the disease.
【学位授予单位】：西安医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.11

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