艾司西酞普兰治疗老年慢性心力衰竭伴抑郁症对患者认知功能和心功能的影响

发布时间：2018-06-05 22:56

本文选题：艾司西酞普兰 + 慢性心力衰竭　；参考：《重庆医学》2017年19期

【摘要】：目的探索治疗老年慢性心力衰竭(CHF)合并抑郁障碍时在常规内科治疗基础上加用艾司西酞普兰对认知功能和心功能的近期影响。方法选取2014年10月至2015年10月重庆市第九人民医院收治的97例CHF合并抑郁障碍患者,随机分为抗抑郁组和对照组。抗抑郁组在常规内科治疗基础上加用艾司西酞普兰,对照组则加用安慰剂。治疗前和治疗6周末采用24项汉密尔顿抑郁量表(HAMD-24)、14项汉密尔顿焦虑量表(HAMA-14)、蒙特利尔认知评估量表(MoCA)评估患者的抑郁、焦虑程度和认知功能,并检测患者血浆N-末端脑利钠肽原(NT-proBNP)水平、左心室舒张末内径(LVEDD)及左心室射血分数(LVEF)。结果治疗6周末,抗抑郁组HAMD-24和HAMA-14得分、血浆NT-ProBNP水平低于对照组,注意得分和LVEF高于对照组,差异均有统计学意义(P0.05);其余各项观察指标比较,差异无统计学意义(P0.05)。结论艾司西酞普兰治疗老年CHF合并抑郁障碍不仅能缓解患者的焦虑抑郁情绪,还能促进患者心功能和注意的改善。
[Abstract]:Objective to explore the short-term effects of Escitalopram on cognitive function and cardiac function in elderly patients with chronic heart failure (CHF) complicated with depressive disorder on the basis of routine medical treatment. Methods from October 2014 to October 2015, 97 patients with CHF complicated with depressive disorder in Chongqing Ninth people's Hospital were randomly divided into antidepressant group and control group. The antidepressant group was treated with estalopram on the basis of routine medical treatment and the control group with placebo. Before and after 6 weeks of treatment, 24 items of Hamilton Depression scale (Hamd) and 14 items of Hamilton anxiety scale (Hamilton anxiety scale) and Montreal Cognitive Assessment scale (MOCA) were used to evaluate the depression, anxiety and cognitive function of the patients. Plasma NT-proBNPs, left ventricular end-diastolic diameter (LVEDDD) and left ventricular ejection fraction (LVEF) were measured. Results at the end of 6 weeks, the scores of HAMD-24 and HAMA-14, the level of plasma NT-ProBNP in antidepressant group were lower than those in the control group, the attention score and LVEF were higher than those in the control group, the difference was statistically significant (P 0.05), but there was no significant difference in other observation indexes (P 0.05). Conclusion Escitalopram can not only relieve anxiety and depression, but also improve cardiac function and attention in elderly patients with CHF combined with depression.
【作者单位】：重庆市第九人民医院心身医学科;重庆医科大学第一附属医院心理卫生中心;重庆市第九人民医院心血管内科;
【基金】：重庆市科委《重庆市应用开发计划项目》一般项目(cstc2014yykfA110030)
【分类号】：R541.6;R749.4

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