慢性感染及炎症反应与冠状动脉病变程度的相关性研究

发布时间：2018-06-06 02:49

本文选题：冠状动脉病变 + 肺炎衣原体　；参考：《中华医院感染学杂志》2017年09期

【摘要】：目的探讨冠状动脉病变程度与微生物慢性感染及炎症反应的关系。方法选取2015年9月-2016年9月冠心病患者150例为观察组,按冠状动脉病变支数进行分组,以同期50例健康体检者为对照组,ELISA测定患者血清肺炎衣原体抗体(Cpn-IgG,Cpn-IgA)、幽门螺杆菌抗体(HP-IgG)、人类巨细胞病毒抗体(HCMV-IgG)水平,生化仪测定C-反应蛋白(CRP)及白细胞(WBC)计数,比较Cpn-IgG、Cpn-IgA、HP-IgG、HCMV-IgG、CRP、WBC与不同冠状动脉病变程度的关系。结果观察组中,三支病变组、双支病变组及单支病变组与对照组比较,Cpn-IgG、HP-IgG、HCMV-IgG阳性率均显著升高,差异有统计学意义(χ2=9.2384,14.1228,7.6054,P0.05),观察组不同支数病变组患者Cpn-IgG、HP-IgG、HCMV-IgG均高于对照组;观察组中,随着病变程度的加重,Cpn-IgG、HP-IgG、HCMV-IgG升高,差异有统计学意义(P0.05),观察组中3种不同冠脉病变程度的Cpn慢性感染率分别为:单支病变组为18.00%、双支病变组为33.33%、三支病变组为71.42%;观察组Cpn慢性感染率为40.67%,显著高于对照组,差异有统计学意义(P0.01);观察组中,不同支数病变组患者Cpn-IgA的截断指数值均高于对照组;观察组中,双支病变组、三支病变组与单支病变组患者相比,血清CRP及WBC水平均显著升高,差异有统计学意义(P0.05);不同冠状动脉病变程度的患者血清Cpn-IgA与CRP及WBC之间呈正相关(P0.01);CRP与WBC亦呈正相关(P0.01)。结论血清Cpn-IgA水平与冠状动脉病变程度有一定的关系,在冠状动脉病变过程中有炎症反应的参与。
[Abstract]:Objective to investigate the relationship between the severity of coronary artery disease and microorganism chronic infection and inflammatory reaction. Methods 150 patients with coronary heart disease from September 2015 to September 2016 were selected as observation group and divided into two groups according to the number of coronary artery disease branches. The serum levels of chlamydia pneumoniae antibody (Cpn-IgG), Helicobacter pylori antibody (HP-IgG), human cytomegalovirus antibody (HCMV-IgG) were measured by Elisa in 50 healthy controls. The levels of C-reactive protein (CRP) and white blood cell (WBC) were measured by biochemical instrument. To compare the relationship between Cpn-IgG, Cpn-IgA, HP-IgG, HCMV-IgP, WBC and different severity of coronary artery disease. Results compared with the control group, the positive rate of Cpn-IgGG HP-IgMV-IgG in the three-vessel lesion group, the two-vessel lesion group and the single-vessel lesion group was significantly higher than that in the control group (蠂 ~ 29.2384 ~ 14.12287.6054, P 0.05, 蠂 ~ 29.2384 ~ 14.12287.6054, P 0.05), and the level of HCMV-IgG in the observation group was significantly higher than that in the control group, while in the observation group, the level of HCMV-IgG was significantly higher in the observation group than in the control group (蠂 ~ 2 9.2384). The HCMV-IgG increased with the severity of the lesion. The chronic infection rate of Cpn was 18.00 in the single vessel lesion group, 33.33 in the double vessel lesion group, 71.42 in the three-vessel lesion group, and the chronic infection rate of Cpn in the observation group was 40.67, which was significantly higher than that in the control group. In the observation group, the truncation index of Cpn-IgA in the patients with different branch lesions was higher than that in the control group, in the observation group, the serum CRP and WBC levels in the double-vessel lesion group and the three-vessel lesion group were significantly higher than those in the single-vessel lesion group. There was a positive correlation between serum Cpn-IgA, CRP and WBC in patients with different degrees of coronary artery disease. There was also a positive correlation between P0.01CRP and WBC in patients with different degrees of coronary artery disease. Conclusion the level of serum Cpn-IgA is related to the severity of coronary artery disease, and inflammation is involved in the process of coronary artery disease.
【作者单位】：安阳市人民医院心血管内科一病区;安阳市人民医院呼吸内科;安阳市人民医院心血管内科三病区;安阳市人民医院心脏外科;
【基金】：河南省基础与前沿技术研究基金资助项目(103401110239)
【分类号】：R541.4

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