冠心病患者外周血miR-21的表达及与冠状动脉病变程度的关系

发布时间：2018-06-06 05:31

本文选题：冠心病 + miR-表达　；参考：《中国老年学杂志》2017年02期

【摘要】：目的探讨冠心病(CHD)患者外周血miR-21的表达及与冠状动脉病变严重程度的相关性。方法行冠脉造影的患者145例中CHD患者77例,其中心绞痛(AP)45例(AP组)及急性心肌梗死(AMI)32例(AMI组),另外无冠脉病变68例为对照组。采用Gensni评分评价冠脉狭窄程度,应用荧光实时定量(qRT-PCR)方法检测外周血miR-21表达。结果三组血浆中miR-21表达水平、Gensini评分及冠脉狭窄程度差异显著(P0.05),其中AMI组、AP组血浆中miR-21表达水平、Gensini评分及冠脉狭窄程度显著高于对照组,AMI组亦显著高于AP组(P0.05);Spearman线性相关分析显示,CHD患者miR-21表达水平与Gensini评分、冠脉狭窄程度呈正相关性(r=0.895、0.888,均P0.05)。结论 CHD患者外周血miR-21高表达,且与冠脉病变的严重程度具有正相关性,为CHD临床诊治及预后提供了理论依据。
[Abstract]:Objective to investigate the expression of miR-21 in peripheral blood of patients with coronary artery disease (CHD) and its correlation with severity of coronary artery disease. Methods among the 145 patients undergoing coronary angiography, 77 were CHD patients, including 45 patients with angina pectoris (AP group), 32 patients with acute myocardial infarction (AMI), and 68 patients without coronary artery disease (control group). The degree of coronary stenosis was evaluated by Gensni score and the expression of miR-21 in peripheral blood was detected by fluorescence real-time quantitative qRT-PCR. Results the levels of miR-21 expression and the severity of coronary stenosis were significantly different among the three groups (P 0.05). In the AMI group, the plasma miR-21 expression level was significantly higher than that in the control group (P 0.05) and the degree of coronary stenosis was significantly higher than that in the AP group (P 0.05) and the degree of coronary stenosis was significantly higher than that in the control group (P 0.05). Correlation analysis showed that the level of miR-21 expression and Gensini score in patients with CHD. There was a positive correlation between the degree of coronary stenosis and the degree of coronary stenosis (P 0.05). Conclusion the high expression of miR-21 in peripheral blood of patients with CHD is positively correlated with the severity of coronary artery disease, which provides a theoretical basis for the clinical diagnosis, treatment and prognosis of CHD.
【作者单位】：濮阳市人民医院心内二科;
【分类号】：R541.4

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