21q22.11位点与冠心病遗传易感性的相关性

发布时间：2018-06-07 14:35

  本文选题：q.位点 + 单核苷酸多态性　； 参考：《中国老年学杂志》2017年12期

【摘要】：目的探讨21q22.11位点与中国广东地区汉族人群冠心病遗传易感性的相关性。方法采用病例对照研究方法,初筛人群包括887例冠心病患者和787例对照者,验证人群包括698例冠心病患者和759例对照者,均来自2012年9月至2013年12月广东医学院附属医院心内科住院患者及同期健康体检者,采用直接测序的方法,对21q22.11位点所选的标签单核苷酸多态性(SNPs)rs9982601、rs7282240、rs1107763、rs1114333、rs8129269、rs12627487位点进行分型,采用非条件逻辑回归分析统计21q22.11位点与中国广东地区汉族人群冠心病的相关性。结果21q22.11位点标签SNP rs9982601在初筛人群中无多态性;标签SNPs rs7282240、rs1107763、rs1114333、rs8129269的等位基因频率分布在初筛人群中冠心病组与对照组差异无统计学意义(P0.05);rs12627487在初筛人群中冠心病组与对照组的等位基因频率差异有统计学意义[P(Logistic)=0.043],随后验证SNP rs12627487,该SNPs在验证人群冠心病组及对照组中等位基因频率差异无统计学意义(P0.05)。合并人群后rs12627487在冠心病组及对照组中等位基因频率差异无统计学意义(P0.05);进一步对年龄、体重指数(BMI)、吸烟、高血压、糖尿病及高脂血症进行分层分析仍无统计学意义(P0.05)。结论 21q22.11位点标签SNPs rs9982601、rs7282240、rs1107763、rs1114333、rs8129269、rs12627487位点多态性与中国广东地区汉族人群冠心病发病无明显相关。
[Abstract]:Objective to investigate the relationship between 21q22.11 locus and genetic susceptibility to coronary heart disease (CHD) in Chinese Han population. Methods A case-control study was conducted. The primary screening population consisted of 887 patients with coronary heart disease and 787 controls. The validated population included 698 patients with coronary heart disease and 759 controls. From September 2012 to December 2013, all inpatients in Department of Cardiology, affiliated Hospital of Guangdong Medical College, and health examiners were divided into two groups. The single nucleotide polymorphisms rs9982601, rs7102240, rs1114333rs11129269rs12627487 were identified by direct sequencing. Non-conditional logistic regression analysis was used to analyze the correlation between 21q22.11 locus and coronary heart disease (CHD) in Chinese Han population. Results the 21q22.11 locus label SNP rs9982601 was not polymorphic in the primary screening population. The allele frequency of the label SNPs rs7282240 rs1107763rs1114333rs8129269 was not significantly different between the CHD group and the control group in the primary screening population. There was significant difference in allele frequency between the CHD group and the control group in the primary screening group [P(Logistic)=0.043]. SNP rs12627487. There was no significant difference in allele frequency between CHD group and control group (P 0.05). There was no significant difference in allele frequency of rs12627487 between CHD group and control group (P 0.05), and there was no significant difference in age, body mass index (BMI), smoking, hypertension, diabetes mellitus and hyperlipidemia (P 0.05). Conclusion the polymorphism of SNPs rs9982601rs7282240rs1107763rs1114333rs8129269rs12627487 has no significant correlation with the incidence of coronary heart disease in the Han nationality population in Guangdong, China.
【作者单位】： 新乡市中心医院心血管内科;广东医科大学附属医院心血管内科;
【基金】：广东省自然科学基金(S2013010015074)
【分类号】：R541.4
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本文编号：1991521