通窍救心油舌下给药治疗冠心病不稳定型心绞痛30例临床观察

发布时间：2018-06-09 20:48

  本文选题：冠心病 + 不稳定型心绞痛　； 参考：《中医杂志》2017年16期

【摘要】：目的评价通窍救心油舌下给药治疗冠心病不稳定型心绞痛的疗效及安全性。方法选择冠心病不稳定型心绞痛患者118例,随机分为舌下组30例、口服组29例、外搽组31例及对照组28例。在西医标准疗法的基础上,舌下组舌下含服通窍救心油;口服组口服通窍救心油;外搽组用通窍救心油外搽人中穴;对照组口服硝酸异山梨酯片,心绞痛发作时可临时增加1次用药,各组均治疗7天。治疗前后观察每周心绞痛发作次数、胸痛程度积分、胸闷程度积分,并于治疗后评价患者心绞痛缓解时间疗效、心电图疗效及安全性。结果治疗后各组每周心绞痛发作次数、胸痛程度积分、胸闷程度积分、心绞痛缓解时间疗效、心电图疗效均较治疗前好转(P0.05);治疗后舌下组心绞痛缓解时间总有效率与口服组、外搽组、对照组比较差异均无统计学意义,但舌下组每周心绞痛发作次数、胸痛程度积分、胸闷程度积分、心绞痛缓解时间显效率及心电图有效率均优于口服组与外擦组(P0.0167),与对照组比较疗效相当。观察期间,对各组患者试验前后肝、肾功能,血、尿、便常规的异常结果进行了统计描述,各组均无加重。结论通窍救心油舌下给药治疗冠心病不稳定型心绞痛疗效确切且安全,在快速缓解心绞痛、减少心绞痛发作次数、减轻胸痛胸闷程度、改善心电图心肌缺血方面与硝酸异山梨酯片疗效相当,起效时间明显优于外搽及口服给药。
[Abstract]:Objective to evaluate the efficacy and safety of sublingual medication in treating unstable angina pectoris of coronary heart disease. Methods 118 patients with unstable angina pectoris of coronary heart disease were randomly divided into sublingual group (n = 30), oral group (n = 29), external liniment group (n = 31) and control group (n = 28). On the basis of western medicine standard therapy, the sublingual group contained the sublingual oil for relieving the heart through orifices; the oral group took the oil for relieving the heart from the orifices; the external liniment group used the Tongqiao Jiuxin oil for the external application of the human central point; the control group took isosorbide nitrate tablets. Angina pectoris attack can be temporarily increased once, each group were treated for 7 days. The times of angina pectoris attack, the score of chest pain and the score of chest tightness were observed before and after treatment. The curative effect of angina pectoris relief time, the effect of electrocardiogram and the safety of angina pectoris were evaluated after treatment. Results after treatment, the times of angina pectoris attack, the score of chest pain, the score of chest tightness, the curative effect of angina pectoris relief time and the curative effect of electrocardiogram were all better than those before treatment, and the total effective rate of angina pectoris relief in sublingual group was higher than that in oral group. There was no significant difference between the external liniment group and the control group, but the times of angina pectoris, the degree of chest pain and the degree of chest tightness in the sublingual group were not statistically significant. The significant relief rate of angina pectoris and the effective rate of electrocardiogram were better than those of oral group and external rubbing group (P0.0167), and the curative effect was similar to that of control group. During the observation period, the abnormal results of liver, kidney function, blood, urine and stool before and after the test were statistically described. Conclusion it is effective and safe to treat unstable angina pectoris of coronary heart disease by sublingual administration of Tongqiao and Huoxin oil. It can relieve angina pectoris quickly, reduce the number of angina pectoris attacks and relieve chest pain and chest tightness. The improvement of ECG myocardial ischemia was similar to isosorbide nitrate tablets, and the time of effect was significantly better than that of external liniment and oral administration.
【作者单位】： 广州中医药大学;广州中医药大学第一附属医院;
【基金】：广东省省级科技计划项目(2014A020221071)
【分类号】：R541.4
，

本文编号：2000780