乙酰半胱氨酸治疗H型高血压的临床疗效研究

发布时间：2018-06-11 22:24

本文选题：H型高血压 + 乙酰半胱氨酸　；参考：《重庆医学》2017年29期

【摘要】：目的探讨乙酰半胱氨酸治疗H型高血压的临床疗效及吸烟对疗效的影响。方法选取2013年10月至2015年10月于解放军第三二四医院住院或门诊确诊的H型高血压患者80例,分为观察组与对照组(各40例),观察组中吸烟者18例、非吸烟者22例,对照组中吸烟者24例、非吸烟者16例。对照组给予常规降压药物治疗,观察组在常规降压药物治疗的基础上口服乙酰半胱氨酸治疗,8周后比较两组治疗前后血压及血浆同型半胱氨酸(Hcy)水平,以及两组吸烟与非吸烟患者Hcy水平。结果观察组治疗后血浆Hcy水平为(13.1±2.2)μmol/L,明显低于治疗前的(19.1±3.3)μmol/L及对照组治疗后的(19.2±3.2)μmol/L,差异均有统计学意义(P0.05)。治疗后观察组收缩压及舒张压均明显低于治疗前,且观察组收缩压下降(22.9±7.9)mm Hg,高于对照组的(17.2±3.7)mm Hg,舒张压下降(10.5±2.7)mm Hg,高于对照组的(8.9±1.2)mm Hg,差异均有统计学意义(P0.05)。两组中吸烟者与非吸烟者治疗前后血Hcy水平比较,差异均无统计学意义(P0.05)。结论乙酰半胱氨酸治疗H型高血压可显著改善患者血压及血浆Hcy水平,临床疗效显著。
[Abstract]:Objective to investigate the effect of acetylcysteine in the treatment of type H hypertension and the effect of smoking on the curative effect. Methods 80 patients with type H hypertension diagnosed in hospital or outpatient department of PLA 324 hospital from October 2013 to October 2015 were divided into the observation group and the control group (40 cases each), 18 cases in the observation group, 22 non smokers, and the control group. There were 24 smokers and 16 non smokers in the group. The control group was treated with conventional antihypertensive drugs. The observation group was treated with acetyl cysteine on the basis of conventional antihypertensive therapy. After 8 weeks, the blood pressure and plasma homocysteine (Hcy) level in the two groups were compared, and the level of Hcy in two groups of smoking and non-smoking patients. The results were observed in the observation group. The level of plasma Hcy was (13.1 + 2.2) mu mol/L after treatment, which was significantly lower than (19.1 + 3.3) mol/L before treatment and (19.2 + 3.2) mol/L after treatment. The difference was statistically significant (P0.05). The systolic pressure and diastolic pressure of the observation group were significantly lower than those before treatment, and the systolic pressure of the observation group decreased (22.9 + 7.9) mm Hg, which was higher than that of the control group (17.2 + 3.7). Mm Hg, diastolic pressure decreased (10.5 + 2.7) mm Hg, higher than that of the control group (8.9 + 1.2) mm Hg, the difference was statistically significant (P0.05). The difference was not statistically significant (P0.05) in the two groups of smokers and non smokers before and after treatment (P0.05). Conclusion acetyl cysteine treatment of H type hypertension could significantly improve the blood pressure and plasma Hcy level in patients. The effect of bed is remarkable.
【作者单位】：解放军第三二四医院干部病房;重庆市九龙坡区妇幼保健计划生育服务中心;
【基金】：重庆市社会民生科技创新专项基金资助项目(cstc2015shmszx10019) 重庆市科技惠民计划基金资助项目(cstc2015jcsf10001-01-05)
【分类号】：R544.1

【相似文献】