脂蛋白磷脂酶A2和髓过氧化物酶与超敏C反应蛋白及全球急性冠状动脉事件注册评分的相关性

发布时间：2018-06-13 12:00

本文选题：冠心病 + 脂蛋白磷脂酶A　；参考：《广东医学》2017年03期

【摘要】：目的探讨不同类型冠心病患者外周血脂蛋白磷脂酶A2和髓过氧化物酶水平的变化,及与超敏C反应蛋白和全球急性冠状动脉事件注册评分的相关性。方法选择行冠状动脉造影术的住院患者150例,其中无症状心肌缺血(SMI)组28例,稳定型心绞痛(SAP)组59例,急性冠脉综合征(ACS)组63例,采用酶联免疫吸附试验(ELISA法)测定血清脂蛋白磷脂酶A2、髓过氧化物酶水平,乳胶免疫比浊法测定超敏C反应蛋白水平,并计算患者全球急性冠状动脉事件注册评分,分析脂蛋白磷脂酶A2和髓过氧化物酶与超敏C反应蛋白、全球急性冠状动脉事件注册评分危险分层的关系。结果急性冠脉综合征组外周血血清脂蛋白磷脂酶A2、髓过氧化物酶和超敏C反应蛋白均高于稳定型心绞痛组和无症状心肌缺血组,差异有统计学意义(P0.05);稳定型心绞痛组外周血血清脂蛋白磷脂酶A2、髓过氧化物酶和超敏C反应蛋白水平与无症状心肌缺血组比较,差异均无统计学意义(P0.05);血清脂蛋白磷脂酶A2与髓过氧化物酶、超敏C反应蛋白均呈正相关(r=0.793,P0.05;r=0.769,P0.05),髓过氧化物酶水平与超敏C反应蛋白也呈正相关(r=0.743,P0.05);而血清脂蛋白磷脂酶A2、髓过氧化物酶和超敏C反应蛋白水平与患者全球急性冠状动脉事件注册评分均无相关性。结论联合检测血清脂蛋白磷脂酶A2、髓过氧化物酶和超敏C反应蛋白水平或联合全球急性冠状动脉事件注册评分可能有助于进一步有效评估冠心病危险分层,对冠心病的及时干预和治疗可能有重要意义。
[Abstract]:Objective to investigate the changes of lipoprotein phospholipase A _ 2 and myeloperoxidase in peripheral blood of patients with different types of coronary heart disease and their correlation with high sensitivity C-reactive protein and global acute coronary event registration score. Methods 150 inpatients underwent coronary angiography, including 28 patients with asymptomatic myocardial ischemia, 59 patients with stable angina pectoris and 63 patients with acute coronary syndrome (ACSS), including 28 patients with asymptomatic myocardial ischemia (SI), 59 patients with stable angina pectoris (SAP) and 63 patients with acute coronary syndrome (ACS). Serum lipoprotein phospholipase A _ 2 and myeloperoxidase levels were determined by enzyme-linked immunosorbent assay (Elisa), and the hypersensitive C-reactive protein levels were measured by latex immunoturbidimetry, and the global acute coronary event registration score was calculated. To analyze the relationship between lipoprotein phospholipase A 2 and myeloperoxidase and the risk stratification of high sensitive C reactive protein and global acute coronary event registration score. Results Serum lipoprotein phospholipase A _ 2, myeloperoxidase and hypersensitive C-reactive protein in acute coronary syndrome group were higher than those in stable angina pectoris group and asymptomatic myocardial ischemia group. The levels of serum lipoprotein phospholipase A2, myeloperoxidase and hypersensitive C-reactive protein in patients with stable angina pectoris were compared with those in asymptomatic myocardial ischemia group. There was no significant difference in serum lipoprotein phospholipase A 2 and myeloperoxidase. There was a positive correlation between serum lipoprotein phospholipase A _ 2, myeloperoxidase and hypersensitive C-reactive protein, and the levels of serum lipoprotein phospholipase A _ 2, myeloperoxidase and hypersensitive C-reactive protein were positively correlated with global acute coronation. No correlation was found in the arterial event registration score. Conclusion combined detection of serum lipoprotein phospholipase A _ 2, myeloperoxidase and hypersensitive C-reactive protein levels or global acute coronary event registration score may be helpful for further effective assessment of coronary artery disease risk stratification. The timely intervention and treatment of coronary heart disease may be of great significance.
【作者单位】：南华大学附属第一医院心内科;南华大学附属第二医院药剂科;
【基金】：国家自然科学基金资助项目(编号:81270181,81202830)
【分类号】：R541.4

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