亚临床甲减对冠心病患者血脂、MPV的影响与冠脉病变严重程度的关系

发布时间：2018-06-15 01:10

  本文选题：亚临床甲减 + 冠心病　； 参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:了解亚临床甲减(SCH)对血脂和血小板平均体积(MPV)的影响,探讨其与冠脉病变严重程度的关系。方法:本文回顾性分析在2015年06月至2015年12月在我院心内科住院并经冠脉造影初次确诊为冠心病的患者,据其甲功分为重度亚临床甲减组(22例),轻度亚临床甲减组(71例)和甲功正常组(217例),并记录实验室检查及冠脉造影结果,据病变血管支数、冠脉病变的Gensini积分相应分组。记录人口学特征和既往史,测定他们次日空腹的血生化指标并分析组间差异;比较亚临床甲减和TSH在不同冠脉病变程度分组中患病率和平均水平,观察亚临床甲减与冠脉病变的关系。结果:重度亚临床甲减组(TSH≥10uIU/ml)血脂(TC、LDL、LPa、ApoB)、MPV、Gensini积分较轻度亚临床甲减组(TSH:4.5-9.9mIU/L)和甲功正常组(TSH4.5mIU/L)高,TG水平高于甲功正常组(P0.05)。轻度亚临床甲减组TC和MPV水平高于甲功正常组(P0.05)。亚临床甲减在多支病变组中的患病率较单支病变组高(P0.05)。亚临床甲减患者根据Gensini积分分组后C组(Gensini≥40)在TSH、BUN水平与A组(Gensin积分20)和B组(Gensini积分20-39)比较有统计学意义,在血脂(TC、LDL、LPa)、MPV水平与A组比较有统计学意义。结论:重度亚临床甲减组和轻度亚临床甲减组与甲功正常组相比,血脂水平、血小板平均体积之间存在着差异,重度亚临床甲减对血脂紊乱的影响更大。亚临床甲减多见于多支病变组,多支病变组平均TSH水平较单支病变组高,随着TSH水平越高,Gensini积分越高,冠脉病变范围及狭窄程度越重。
[Abstract]:Objective: to investigate the effects of subclinical hypothyroidism (SCH) on blood lipids and mean platelet volume (MPV) in patients with coronary artery disease. Methods: the patients who were hospitalized in our hospital from June 2015 to December 2015 and were diagnosed with coronary artery disease by coronary angiography were analyzed retrospectively. The patients were divided into severe subclinical hypothyroidism group (n = 22) and mild subclinical hypothyroidism group (n = 71) and normal thyroid function group (n = 217). The results of laboratory examination and coronary angiography were recorded. The demographic characteristics and past history were recorded, the fasting blood biochemical indexes were measured and the differences between the two groups were analyzed, and the prevalence and average levels of subclinical hypothyroidism and TSH in different coronary lesion groups were compared. To observe the relationship between subclinical hypothyroidism and coronary artery disease. Results: in severe subclinical hypothyroidism group (TSH 鈮，

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