骨形成蛋白Ⅱ型受体信号通路与肺动脉高压:新进展与希望

发布时间：2018-06-15 03:33

本文选题：肺动脉高压 + 骨形成蛋白　；参考：《中国药理学与毒理学杂志》2017年02期

【摘要】：骨形成蛋白2型受体(BMPR2)基因突变与肺动脉高压(PAH)关系的揭示被认为是21世纪该研究领域最重大的发现之一。BMPR2基因突变与大部分遗传性PAH和部分特发性PAH患者的发病有关。临床和动物研究均表明,BMPR2介导的BMP信号通路在PAH发生发展过程中扮演重要角色。近年来,不断深入的研究逐步揭示了BMPR2信号通路参与PAH发病的重要机制,以该信号通路为治疗靶点的可能性正被逐渐揭示。本文以BMPR2信号通路与PAH的关系为基础,从遗传学、表观遗传学和炎症反应机制等角度进行综述,介绍PAH研究领域的最新进展。
[Abstract]:The relationship between bone morphogenetic protein type 2 receptor BMPR2 gene mutation and pulmonary hypertension (PAH) is considered to be one of the most important findings in this field in the 21st century. BMPR2 gene mutation is associated with the pathogenesis of most hereditary PAH and some idiopathic PAH patients. Clinical and animal studies have shown that BMPR2-mediated BMP signaling pathway plays an important role in the development of PAH. In recent years, more and more research has revealed the important mechanism of BMPR2 signaling pathway involved in the pathogenesis of PAH, and the possibility of using BMPR2 signal pathway as a therapeutic target has been gradually revealed. Based on the relationship between BMPR2 signaling pathway and PAH, this paper reviews the recent advances in the research of PAH from the perspectives of genetics, epigenetics and inflammatory response mechanism.
【作者单位】：中南大学湘雅药学院药理学系;
【基金】：国家自然科学基金(81200035) 中南大学创新驱动计划(2016CX034)~~
【分类号】：R544.1

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