血清可溶性Sema4D水平与扩张型心肌病心室重构的相关性研究

发布时间：2018-06-15 04:14

本文选题：重组蛋白质类 + 基质金属蛋白酶　；参考：《中国循环杂志》2017年01期

【摘要】：目的 :研究扩张型心肌病慢性心力衰竭患者血清可溶性Sema4D(s Sema4D)与基质金属蛋白酶14(MMP14)水平的变化,探讨s Sema4D与扩张型心肌病慢性心力衰竭心室重构的相关性。方法 :选取86例新入院的扩张型心肌病慢性心力衰竭患者为扩张型心肌病组,32例健康体检者为正常对照组。酶联免疫吸附法检测血清s Sema4D、MMP14、B型利钠肽原(pro BNP)、超敏C反应蛋白(hs-CRP)水平;彩色多普勒超声心动仪检测左心房内径(LAD)、右心室内径(RVD)、左心室射血分数(LVEF)、左心室舒张末期内径(LVDd)、左心室短轴缩短率(LVFS)。对s Sema4D、MMP14及左心室重构指标进行相关性分析。结果 :两组间血清s Sema4D、MMP14水平差异均有统计学意义(P0.001)。扩张型心肌病组血清s Sema4D水平分别与血清MMP14水平、左心室舒张末期内径呈正相关(r=0.462,P0.001;r=0.643,P0.000)。结论 :扩张型心肌病慢性心力衰竭患者血清s Sema4D蛋白与MMP14蛋白水平、左心室舒张末期内径呈正相关。
[Abstract]:Aim: to study the changes of serum soluble Sema4D) and matrix metalloproteinase-14 (MMP14) levels in patients with dilated cardiomyopathy and chronic heart failure, and to explore the relationship between sSema4D and ventricular remodeling in patients with dilated cardiomyopathy. Methods: 86 newly admitted patients with chronic heart failure of dilated cardiomyopathy (DCM) were selected as control group (n = 32). The serum levels of serum s Sema4DX MMP14 B natriuretic peptide proBNPP, hs-CRP were detected by Elisa. The left atrial diameter (lad), right ventricular diameter (RV), left ventricular ejection fraction (LVVEF), left ventricular end-diastolic diameter (LVDdN), left ventricular shortening rate (LVFSN) and left ventricular end diastolic diameter (LVDD) were detected by color Doppler echocardiography. The correlation between s Sema4 DU MMP14 and left ventricular remodeling index was analyzed. Results: there were significant differences in serum s Sema4 DU MMP14 levels between the two groups (P 0.001). The levels of serum s Sema4D and MMP14 in patients with dilated cardiomyopathy were positively correlated with left ventricular end-diastolic diameter. Conclusion: there is a positive correlation between serum s Sema4D protein and MMP14 protein and left ventricular end-diastolic diameter in patients with chronic heart failure of dilated cardiomyopathy.
【作者单位】：郑州大学第一附属医院河南省高等学校临床医学重点学科开放实验室;郑州大学第一附属医院老年心血管科;
【基金】：郑州市老年心力衰竭重点实验室建设项目河南省医学科技攻关计划项目(201403072)
【分类号】：R542.2

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