血府逐瘀汤辅助治疗不稳定型心绞痛的Meta分析

发布时间：2018-06-17 08:13

本文选题：血府逐瘀汤 + 不稳定型心绞痛　；参考：《中国药房》2017年27期

【摘要】：目的:系统评价血府逐瘀汤辅助治疗不稳定型心绞痛的疗效,为临床提供循证参考。方法:计算机检索Pub Med、EMBase、Cochrane图书馆、相关期刊论文(CJFD)、万方数据库、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM),收集血府逐瘀汤联合常规方案(试验组)对比单纯常规方案(对照组)治疗不稳定型心绞痛的随机对照试验(RCT),提取RCT资料并按照Cochrane系统评价员手册5.1.0评价质量后,采用Rev Man 5.2统计软件进行Meta分析。结果:共纳入12项RCT,合计1 252例患者。Meta分析结果表明,试验组患者总有效率[OR=3.56,95%CI(2.49,5.10),P0.001]、血清高密度脂蛋白水平[WMD=0.25,95%CI(0.05,0.45),P=0.01]和心电图改善率[OR=2.76,95%CI(1.97,3.87),P0.001]均显著高于对照组,血清总胆固醇[WMD=-1.14,95%CI(-1.46,-0.82),P0.001]、三酰甘油[WMD=-0.53,95%CI(-0.84,-0.22),P0.001]和C反应蛋白水平[WMD=-0.91,95%CI(-1.14,-0.69),P0.001]均显著低于对照组,差异均有统计学意义。结论:血府逐瘀汤辅助治疗不稳定型心绞痛疗效较好,可显著改善患者血脂和炎症因子水平。
[Abstract]:Objective: to evaluate the efficacy of Xuefu Zhuyu decoction in the treatment of unstable angina pectoris. Methods: a computer-based search of Pub Medsite EMBaseen Cochrane Library, full text Database of Chinese Journals (CJFDN) and Wanfang Database was conducted. The Chinese scientific and technological journal database and the Chinese biomedical literature database (CBM) were collected to collect Xuefu Zhuyu decoction combined with routine regimen (test group) for the randomized controlled trial of treating unstable angina pectoris compared with the control group. After extracting RCT data and evaluating the quality according to Cochrane systematic evaluator manual 5.1.0, Meta-analysis was carried out by using Rev Man 5.2 statistical software. Results: a total of 12 RCTs were included. The results of Meta-analysis showed that the total effective rate of the patients in the trial group was significantly higher than that in the control group [OR3.5695 CIQ 2.49 / 5.10 / P0.001], serum high density lipoprotein (HDL-C) level [WMD-0.25 ~ 95CIT 0.050.45P0.01] and the improvement rate of ECG [OR2.795CII 1.97-3.87p0.001], all of which were significantly higher than those in the control group. Serum total cholesterol [WMD-1.1495], triacylglycerol (WMD-0.53CI-0.22P0.001) and C-reactive protein (WMD-0.91C95CI-1.14-0.69P0.001) were significantly lower than those in the control group (P 0.001). Conclusion: Xuefu Zhuyu decoction is effective in treating unstable angina pectoris and can improve the level of blood lipids and inflammatory factors.
【作者单位】：广州中医药大学第四临床医学院;广州中医药大学第一临床医学院;广州中医药大学第一附属医院;
【基金】：国家中医药管理局资助项目(No.JDZX2015241) 广东省中医药管理局资助项目(No.2015LP01)
【分类号】：R541.4

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