利伐沙班与达比加群对心房颤动患者导管消融围术期抗凝治疗的系统评价

发布时间：2018-06-18 04:40

本文选题：利伐沙班 + 达比加群　；参考：《中国临床药理学杂志》2017年11期

【摘要】：目的系统评价利伐沙班与达比加群对心房颤动患者导管消融围术期抗凝治疗的有效性与安全性。方法检索中国知网、维普、万方、PubMed、Web of Science、EmBase及Cochrane图书馆等数据库,检索时间从建库至2016~(-1)2~(-1)5,查找导管消融围术期利伐沙班与达比加群用于治疗心房颤动患者的临床试验。对纳入的研究进行质量评价,用RevMan5.3软件进行Meta分析,最小成本分析法进行经济学评价。结果共有6篇观察性研究与1篇随机对照试验文献研究符合入选标准。Meta分析结果显示:与达比加群相比,利伐沙班在血栓栓塞事件发生率(RR=1.03,95%CI=0.27~4.00,P0.05)、大出血事件发生率(RR=1.02,95%CI=0.42,2.48,P0.05)与卒中事件发生率(RR=0.87,95%CI=0.17~4.60,P0.05)方面差异均无统计学意义,2组成本比较差异有统计学意义(P0.05)。结论利伐沙班与达比加群治疗心房颤动患者导管消融围术期抗凝治疗有效性与安全性相近,但达比加群具有经济学优势。
[Abstract]:Objective to evaluate the efficacy and safety of Levashaban and Dac+ in perioperative anticoagulant therapy in patients with atrial fibrillation. Methods the databases of China Zhiwang, Weip, Wanfang PubMeden Web of ScienceMem Base and Cochrane Library were searched, and the time from the establishment of the database to the year 2016 was found. The clinical trials of Levashaban and Darbica group in the treatment of atrial fibrillation during the perioperative period of catheter ablation were searched. The quality of the included research was evaluated, Meta-analysis was carried out by Revman 5.3 software, and economics was evaluated by the least cost analysis method. Results A total of 6 observational studies and 1 randomized controlled trial literature study met the inclusion criteria. There was no significant difference in the incidence of thromboembolism events (RRN 1.03C95CII 0.274.00 P0.05, RRRN 1.0295CI0.42 + 2.48P0.05) and stroke events (RRN 0.87c95 CI 0.174.60P0.05). There was significant difference in cost between the two groups (P 0.05P 0.05), and there was no significant difference between the two groups in the incidence of thromboembolic events (RRN 1.03) and stroke events (0.174.60P0.05), and there was no significant difference between the two groups in terms of the incidence of thromboembolic events (RRX) and stroke events (P 0.05). Conclusion the efficacy and safety of anticoagulant therapy in patients with atrial fibrillation during catheter ablation are similar to those in patients with atrial fibrillation.
【作者单位】：暨南大学药学院;
【分类号】：R541.75

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