血清松驰素在急性心肌梗死突发患者中的诊断价值及其对预后的影响

发布时间：2018-06-20 15:21

本文选题：血清松弛素 + 急性心肌梗死　；参考：《中国临床药理学杂志》2017年01期

【摘要】：目的观察血清松驰素在急性心肌梗死突发患者中的诊断价值并比较不同血清松弛素水平对预后的影响。方法选取93例急性心肌梗死患者作为试验组,另选取100例健康志愿者作为对照组。对比2组血清松弛素水平,绘制受试者工作特征(ROC)曲线,确定血清松弛素在急性心肌梗死患者突发诊断中最佳节点,计算其敏感度、特异度和准确度。依据血清松弛素水平,将试验组患者再分为高水平组和低水平组,比较2组预后相关指标:左室舒张末期容积(LVEDV)、左室射血分数(LVEF)和舒张早期与舒张晚期的二尖瓣血流速度比值(E/A)水平,并对比心脏药物不良反应发生率(ADR)。结果试验组血清松弛素水平为(29.58±5.12)ng·mL~(-1),远高于对照组的(9.32±2.96)ng·mL~(-1),差异有统计学意义(P0.05);血清松弛素水平在诊断急性心肌梗死突发中最佳节点为14.25 ng·mL~(-1),其中曲线下面积(AUC比值)为0.834,敏感度为80.65%,特异度为89.00%,准确度为84.97%。高松弛素组的LVEDV为(81.06±7.32)mL,明显低于低松弛素组的(95.38±7.82)mL,差异有统计学意义(P0.05);高松弛素组LVEF为(55.89±6.21)%、E/A为1.19±0.21,明显高于低松弛素组LVEF值的(46.13±5.75)%和E/A值的0.85±0.23,差异有统计学意义(P0.05);高松弛素组的ADR为3.85%,远低于低松弛素组的24.39%,差异有统计学意义(P0.05)。结论血清松弛素在急性心肌梗死患者中明显升高,可用于心肌梗死的突发诊断和预后评估。
[Abstract]:Objective to observe the diagnostic value of serum relaxins in patients with acute myocardial infarction (AMI) and to compare the effect of different levels of serum relaxin on prognosis. Methods 93 patients with acute myocardial infarction were selected as trial group and 100 healthy volunteers as control group. The serum levels of relaxin were compared and the ROCcurves were drawn to determine the optimal node of serum relaxin in the diagnosis of acute myocardial infarction and to calculate its sensitivity, specificity and accuracy. According to the level of serum relaxin, the patients in the test group were subdivided into high level group and low level group. The prognostic parameters of the two groups were compared: left ventricular end-diastolic volume (LVEF), left ventricular ejection fraction (LVEF) and mitral valve velocity ratio (E / A) in early to late diastolic phase, and the incidence of adverse cardiac drug reactions was compared. Results the level of serum relaxin in the trial group was 29.58 卤5.12)ng mLL-1, which was much higher than that in the control group (9.32 卤2.96)ng mLL-1), the difference was statistically significant (P 0.05), and the optimal level of serum relaxin in the diagnosis of acute myocardial infarction burst was 14.25 ng mLML-1, in which the area under curve AUC ratio was 0.834, and that in the control group was higher than that in the control group (P < 0.05), and the level of serum relaxin in the experimental group was higher than that in the control group (P < 0.05). The sensitivity was 80.65, the specificity was 89.00 and the accuracy was 84.97. The LVEDV in the hyperrelaxation group was 81.06 卤7.32 mL, which was significantly lower than that in the low-relaxation group (95.38 卤7.82 mL, P 0.05), the LVEF in the hyperrelaxation group was 1.19 卤0.21, which was significantly higher than that in the low-relaxation group (46.13 卤5.75g% and 0.85 卤0.23). The ADR of the group was 3.85, which was much lower than that of the low relaxin group (24.39%), the difference was statistically significant (P 0.05). Conclusion Serum relaxin is significantly increased in patients with acute myocardial infarction and can be used in the diagnosis and prognosis evaluation of myocardial infarction.
【作者单位】：东营胜利石油管理局胜利医院心内科;东营胜利石油管理局胜利医院精神卫生康复中心;山东大学第二医院心内科;
【基金】：山东省自然科学基金资助项目(2014ZRE27592)
【分类号】：R542.22

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