糖脂代谢对原发性高血压病人血管内皮功能的影响

发布时间：2018-06-21 01:15

本文选题：原发性高血压 + 血管内皮功能　；参考：《首都医科大学学报》2017年03期

【摘要】：目的探讨糖脂代谢对原发性高血压病人血管内皮功能的影响。方法连续入选2016年01月至2016年12月于首都医科大学宣武医院心脏科门诊初次诊断为原发性高血压病人111例,所有病人均检测血液生物化学指标及血管内皮功能测试以得到血糖、血脂及反应性充血指数(reactive hyperemia index,RHI)。依据RHI值分为RHI正常组(63例,RHI1.67)及RHI减低组(48例,RHI1.67)。应用相关分析和多元线性回归分析血糖血脂与原发性高血压病人RHI的相关性。结果 RHI减低组在收缩压(systolic blood pressure,SBP)、空腹血糖(glucose,GLU)、糖化血红蛋白(glycosylated hemoglobin,Hb A1c)、低密度脂蛋白(low density lipoprotein-cholesterol,LDL-C)等方面均高于RHI正常组,差异有统计学意义(P0.05)。Pearson相关分析显示,SBP、GLU、Hb A1c和LDL-C均与RHI呈负相关(P0.05)。多元线性回归分析结果显示:SBP、LDL-C和GLU是影响RHI的独立危险因素,均与RHI呈负相关。结论高血糖和高血脂会加重原发性高血压病人的血管内皮功能障碍。
[Abstract]:Objective to investigate the effect of glucose and lipid metabolism on vascular endothelial function in patients with essential hypertension. Methods from January 2016 to December 2016, 111 patients with essential hypertension were first diagnosed in the Department of Cardiology, Xuanwu Hospital, Capital Medical University. All the patients were tested for blood biochemical indexes and vascular endothelial function test to get blood glucose. Serum lipids and reactive hyperemia index (RHI). According to RHI value, 63 cases of RHI in normal RHI group and 48 cases of RHI 1.67 in RHI decreased group were divided into two groups. Correlation analysis and multiple linear regression analysis were used to analyze the correlation between blood glucose, blood lipid and RHI in patients with essential hypertension. Results the systolic blood pressure, fasting blood glucose, glycosylated hemoglobulin HbA1cn, low density lipoprotein low density lipoprotein-cholesterol (LDL-C3) were significantly higher in the RHI group than in the normal group, and the correlation analysis showed that there was a negative correlation between SBPG GLUUHbA1c and RHI. Multiple linear regression analysis showed that LDL-C and GLU were independent risk factors for RHI, which were negatively correlated with RHI. Conclusion hyperglycemia and hyperlipidemia may aggravate vascular endothelial dysfunction in patients with essential hypertension.
【作者单位】：首都医科大学宣武医院心脏科;
【基金】：基金项目:心血管疾病精准医学北京实验室(PXM2016_014226_000023)~~
【分类号】：R544.11

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