系统性红斑狼疮合并肺动脉高压83例临床分析

发布时间：2018-06-21 03:06

  本文选题：系统性红斑狼疮 + 肺动脉高压　； 参考：《新疆医科大学》2015年硕士论文

【摘要】：目的：通过分析系统性红斑狼疮(systemic lupus erythematosus,SLE)合并肺动脉高压(pulmonary arterial hypertension, PAH)的临床特点,讨论PAH在SLE中的致病原因、相关临床特征及预后影响因素,从而提高对SLE继发PAH的认识。方法：回顾性总结分析2008年1月至2014年1月期间,在新疆医科大学第一附属医院皮肤科及风湿免疫科住院的187例SLE患者中83例经心脏超声多普勒诊断明确、资料完整的合并PAH患者。结果：PAH组与非PAH组患有雷诺现象(42.1%vs13.5%)、指端血管炎(44.6% vs 10.6%)、活动后胸闷(32.5%vs17.3%)、肺间质病变(69.9%vs14.4%)、SLEDAI评分(21.5±5.21vs12.7±6.39)相比较差异有统计学意义(P0.05)；两组之间在年龄、性别、病史、关节炎、口腔溃疡、光敏感、发热等指标相比较差异无统计学意义(P0.05)；结论：对于出现活动后胸闷、雷诺现象、指端血管炎和肺间质病变的SLE患者应警惕PAH的可能,心脏超声多普勒及相关检查有利于早期诊断。
[Abstract]:Objective: to analyze the clinical features of systemic lupus erythematosus (lupus) associated with pulmonary hypertension (lupus), and to discuss the etiology, clinical characteristics and prognostic factors of pulmonary hypertension (PAHs), so as to improve the understanding of PAHs secondary to systemic lupus erythematosus (SLE). Methods: from January 2008 to January 2014, a total of 187 SLE patients hospitalized in the Department of Dermatology and Rheumatological Immunology, first affiliated Hospital of Xinjiang Medical University, were analyzed retrospectively. PAH patients with complete data. Results there were significant differences in the Reynolds phenomenon between the two groups (44.1% vs 10.6%, 44.6% vs 10.6%), chest tightness after exercise (32.5 vs 17.33), interstitial lesion of lung (69.9 vs 14.4) and SLEDAI score of 21.5 卤6.39 (P 0.05), age, sex, history of disease, arthritis, oral ulceration, ulcer, ulceration, etc. There was no significant difference in light sensitivity and fever (P 0.05). Conclusion: patients with SLE with active chest tightness, Raynaud phenomenon, phalanx vasculitis and pulmonary interstitial disease should be alert to the possibility of PAH. Doppler echocardiography and related examination are helpful for early diagnosis.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R593.241;R544.1
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本文编号：2046915