缬沙坦对老年高血压伴阵发性房颤患者相关指标的影响

发布时间：2018-06-24 06:31

本文选题：阵发性房颤 + 老年　；参考：《中国药房》2017年30期

【摘要】：目的:探讨缬沙坦对老年高血压伴阵发性房颤患者相关指标的影响。方法:128例老年高血压伴阵发性房颤患者随机分为观察组和对照组,每组64例。对照组患者给予苯磺酸氨氯地平片5~10 mg/d,每日1次+氢氯噻嗪片12.5 mg/d,每日1次,清晨口服;观察组患者在对照组治疗基础上加用缬沙坦胶囊80~160 mg/d,每日1次,清晨口服。两组疗程均为12周。观察并比较两组患者治疗前后超敏C反应蛋白(Hs-CRP)、白细胞介素6(IL-6)、血压水平和左室射血分数(LVEF)、左心房内径(LAD)、P波最大时限(P_(max))、P波离散度(P_d)以及不良反应发生情况。结果:治疗前,两组患者上述各项指标比较,差异均无统计学意义(P0.05)。治疗后,两组患者Hs-CRP、IL-6水平和LAD均显著低于同组治疗前,且观察组Hs-CRP和IL-6水平显著低于对照组,但LAD显著高于对照组;LVEF显著高于同组治疗前,但观察组显著低于对照组,差异均有统计学意义(P0.05);血压水平均显著低于同组治疗前(P0.05),但组间比较差异无统计学意义(P0.05)。观察组患者Pmax和Pd均显著低于同组治疗前,且显著低于同期对照组(P0.05),而对照组患者Pmax和Pd治疗前后比较,差异均无统计学意义(P0.05)。治疗期间两组患者均未见明显不良反应发生。结论:缬沙坦治疗老年高血压伴阵发性房颤可以显著改善患者血清炎症因子水平和心脏功能相关指标,且安全性较好。
[Abstract]:Objective: to investigate the effect of valsartan on related indexes in elderly hypertensive patients with paroxysmal atrial fibrillation. Methods 128 elderly patients with hypertension with paroxysmal atrial fibrillation were randomly divided into observation group (n = 64) and control group (n = 64). The patients in the control group were given amlodipine benzenesulfonic acid tablets (5g / d), hydrochlorothiazide tablets (12.5 mg / d) once a day, orally in the morning, and the patients in the observation group were given valsartan capsules 80 ~ 160 mg / d, once a day, in the morning, on the basis of the treatment in the control group. The course of treatment was 12 weeks in both groups. To observe and compare the hypersensitive C-reactive protein (Hs-CRP), interleukin-6 (IL-6), blood pressure and left ventricular ejection fraction (LVEF), left atrial diameter (lad) and P wave dispersion (PD) before and after treatment. Results: before treatment, there was no significant difference between the two groups (P0.05). After treatment, the levels of Hs-CRP IL-6 and lad in the two groups were significantly lower than those before treatment, and the levels of Hs-CRP and IL-6 in the observation group were significantly lower than those in the control group, but the lad level was significantly higher than that in the control group and LVEF was significantly higher than that in the control group, but in the observation group was significantly lower than that in the control group. The differences were statistically significant (P0.05), blood pressure levels were significantly lower than the same group before treatment (P0.05), but there was no significant difference between the groups (P0.05). Pmax and PD in the observation group were significantly lower than those in the same group before treatment and significantly lower than that in the control group (P0.05), while in the control group there was no significant difference before and after treatment (P0.05). No significant adverse reactions occurred in both groups during treatment. Conclusion: valsartan in the treatment of elderly hypertension with paroxysmal atrial fibrillation can significantly improve the level of serum inflammatory factors and cardiac function related indicators, and the safety is good.
【作者单位】：南通市海安县中医院心内科;
【分类号】：R541.75;R544.1

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