牙周炎与冠心病之间联系机制的研究进展

发布时间：2018-06-24 09:34

本文选题：牙周炎 + 冠心病　；参考：《口腔医学研究》2017年04期

【摘要】：牙周炎已成为成人失牙的首要原因,调查显示全球约有44%~57%和10%的成人患有中度和重度牙周炎。而冠状动脉粥样硬化性心脏病(CHD)是临床上死亡率较高的疾病之一,严重危害着人类健康,其主要病理学基础是动脉粥样硬化(AS)和在斑块破裂基础上形成的血栓。牙周炎和冠心病之间存在着一定的联系,牙周致病菌通过直接作用定植在冠状动脉;通过间接作用产生各种细胞因子、黏附分子,引起全身炎症状态、脂质异常和凝血状态;激活固有免疫系统,分别形成生物性炎症、化学性炎症、免疫性炎症,最终形成和加重动脉粥样硬化,继而形成冠心病。本文旨在对牙周炎与冠心病之间联系机制的研究进展作一综述。
[Abstract]:Periodontitis has become the leading cause of tooth loss in adults, with about 44, 57 percent and 10 percent of adults worldwide suffering from moderate and severe periodontitis. Coronary atherosclerotic heart disease (CHD) is one of the diseases with high clinical mortality, which seriously endangers human health. The main pathological basis of CHD is atherosclerosis (as) and thrombosis based on plaque rupture. Periodontitis and coronary heart disease have a certain relationship, periodontal pathogenic bacteria through direct action in the coronary artery, through indirect action to produce a variety of cytokines, adhesion molecules, causing systemic inflammation, lipid abnormalities and coagulation state; Activation of the inherent immune system, respectively to form biological inflammation, chemical inflammation, immune inflammation, and ultimately form and aggravate atherosclerosis, and then form coronary heart disease. This article reviews the mechanism of periodontitis and coronary heart disease.
【作者单位】：兰州大学口腔医学院;西北民族大学口腔医学院;
【基金】：国家自然科学基金地区项目(编号:31560159/C0309);国家自然科学基金地区项目(编号:31360124/C0309) 甘肃省科技支撑项目(编号:144WCGA167)
【分类号】：R781.42;R541.4

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