PCI术后血小板聚集功能影响因素的临床分析

发布时间：2018-06-24 15:12

  本文选题：血小板聚集率 + CYPC基因多态性　； 参考：《中国动脉硬化杂志》2017年05期

【摘要】：目的探讨经皮冠状动脉介入(PCI)术后患者血小板聚集功能的影响因素。方法 266例冠心病行PCI的患者,均予以氯吡格雷和阿司匹林双联抗血小板及冠心病标准治疗,根据术后血小板聚集率(PAR)分为0%~29%、30%~49%、50%~69%、70%~100%等4组,比较4组患者的CYP2C19基因型、一般临床信息、冠状动脉病变情况及生化指标,并通过Logistic回归分析,找出PAR升高的危险因素。结果患者的性别构成比、年龄、脑钠肽(BNP)、CYP2C19基因型在不同PAR分组间存在差异(P0.05)。Logistic回归分析显示,PAR升高≥50%的危险因素是女性(OR=2.713,P=0.027)、高BNP(OR=1.002,P=0.007)、CYP2C19呈慢代谢型(OR=5.159,P0.001);PAR升高≥70%的独立危险因素是女性(OR=5.716,P=0.008)、CYP2C19呈慢代谢型(OR=3.149,P=0.049)。结论 PAR50%的患者以CYP2C19快代谢基因型为主,而慢代谢基因型的患者PAR多为50%以上,CYP2C19基因多态性对PAR影响显著。另外,女性、高BNP可能是冠心病患者PCI术后PAR升高的危险因素。
[Abstract]:Objective to investigate the influencing factors of platelet aggregation after percutaneous coronary intervention (PCI). Methods 266 patients who underwent PCI were treated with clopidogrel and aspirin combined anti-platelet therapy and coronary heart disease standard. According to the postoperative platelet aggregation rate (par), the patients were divided into 4 groups, including 50, 29g, 30g, 49g, 50g, 6949g, 70,70,100%, etc. The genotypes of CYP2C19 were compared among the 4 groups. General clinical information, coronary artery disease and biochemical indexes were analyzed. Logistic regression analysis was used to find out the risk factors of par elevation. Results the sex composition ratio, age of the patients, There were significant differences in CYP2C19 genotypes among different par groups (P0.05). Logistic regression analysis showed that the risk factors of increased par 鈮，

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