硫化氢对不同周龄自发性高血压大鼠脑基底动脉舒张反应的影响

发布时间：2018-06-25 09:08

本文选题：自发性高血压大鼠 + 脑基底动脉　；参考：《安徽医科大学学报》2017年06期

【摘要】：目的探讨硫化氢(H_2S)对不同周龄自发性高血压大鼠(SHR)离体脑基底动脉舒张反应的影响。方法选取14、40周龄SHR和正常Wistar京都(WKY)大鼠各6只,测量血压后,急性分离脑基底动脉,应用压力肌动图技术检测不同浓度硫氢化钠(NaHS)对大鼠脑基底动脉直径变化的影响。结果 (1)10、30、100、300、1 000、3 000 mmol/L的NaHS能够浓度依赖地舒张SHR和WKY大鼠脑基底动脉;(2)与14周龄的WKY相比,1 000、3 000 mmol/L的Na HS对14周龄SHR的舒张率更明显,两者间有显著性差异(P0.05);(3)与40周龄的WKY大鼠相比,1 000、3 000 mol/L的NaHS对40周龄SHR的舒张率降低,两者间有显著性差异(P0.05)。结论在高血压初期,脑基底动脉对H_2S的敏感性增加,而随着高血压的发展及血管功能的严重损伤,脑基底动脉可能对H_2S的敏感性降低。
[Abstract]:Objective to investigate the effect of hydrogen sulfide (H _ 2S) on diastolic response of isolated cerebral basilar artery in spontaneously hypertensive rats (SHR) of different weeks. Methods six SHR and six normal Wistar Kyoto (WKY) rats aged 14 and 40 weeks were selected. After blood pressure was measured, the cerebral basilar artery was separated. The effect of sodium sulfide (NaHS) at different concentrations on the diameter of cerebral basilar artery in rats was detected by pressure actin technique. Results (1) the basilar arteries of SHR and WKY rats could be dilated in a concentration-dependent manner by NaHS at 10, 30, 100, 000, 000, 000, 000 mmol / L, (2) the relaxation rate of 1 000 ~ 3 000 mmol / L NaHS on SHR at 14 weeks was more obvious than that of WKY at 14 weeks old, and the relaxation rate of NAHS was significantly higher than that of WKY at 14 weeks of age. There was a significant difference between the two groups (P0.05); (3) and 40 weeks old WKY rats compared with the 40 week old WKY rats, the relaxation rate of 10 000 mol / L NaHS was significantly lower than that of 40 week old WKY rats (P0.05). Conclusion in the early stage of hypertension, the sensitivity of cerebral basilar artery to H2S is increased, but with the development of hypertension and the serious injury of vascular function, the sensitivity of cerebral basilar artery to H2S may decrease.
【作者单位】：石河子大学医学院生理学教研室;石河子大学医学院病理生理学教研室;
【基金】：国家自然科学基金(编号:31460264、81460098、81560081、81600325、81660271)
【分类号】：R544.1

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