住院心房颤动患者血管性认知障碍及相关危险因素分析

发布时间：2018-07-01 19:47

  本文选题：心房颤动 + 认知障碍　； 参考：《中国循环杂志》2017年10期

【摘要】：目的:探讨住院心房颤动(房颤)患者血管性认知功能障碍(VCI)的发生率及相关危险因素。方法:选择兰州大学第二医院住院的房颤患者303例,根据简易智能状态检查量表(MMSE)评分分为无VCI组216例,VCI组87例。评估住院房颤患者VCI的发生率,并对VCI进行单因素及多因素分析。结果:与无VCI组比较,VCI组年龄较大,CHA2DS2-VASC评分≥2分、持续/永久性房颤、合并糖尿病及心力衰竭的比例、收缩压、平均动脉压、脉压,左心房前后径及血肌酐较高,男性比例及左心室舒张末内径较低,差异具有统计学意义(P0.05或P0.001)。住院房颤患者VCI发生率为40.3%,随着年龄的增大、CHA2DS2-VASC评分的增高,VCI发生率增加,女性VCI发生率高于男性,持续及永久性房颤患者VCI发生率高于阵发性房颤患者(P0.05或P0.001)。多元线性回归分析显示,年龄(OR=-0.1135,95%CI:-0.1708~-0.0562,P=0.0001)、女性(OR=-1.2528,95%CI:-2.2056~-0.3000,P=0.0105)、文化水平(小学OR=3.2193,95%CI:1.8446~4.5940,P0.0001;初中及以上OR=5.9104,95%CI:4.6055~7.2154,P0.0001)、心力衰竭(OR=-1.9357,95%CI:-3.5522~-0.3192,P=0.0196)、脑卒中(OR=-1.6349,95%CI:-2.7517~-0.5181,P=0.0044)及左心房前后径(OR=-0.1252,95%CI:-0.1962~-0.0541,P=0.0006)与住院房颤患者VCI发生相关。结论:住院房颤患者VCI发生率高,高龄、女性、较低文化水平、心力衰竭、脑卒中及左心房前后径扩大是房颤患者发生VCI的相关危险因素。
[Abstract]:Objective: to investigate the incidence and risk factors of vascular cognitive impairment (VCI) in hospitalized patients with atrial fibrillation (AF). Methods: 303 patients with atrial fibrillation were selected from the second Hospital of Lanzhou University. According to the MMSE score, they were divided into two groups: 216 patients without VCI and 87 patients with VCI. To evaluate the incidence of VCI in patients with atrial fibrillation, and to analyze the single factor and multivariate analysis of VCI. Results: compared with the VCI group, the older VCI group with CHA2DS2-VASC score 鈮，

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