微粒与溶血性贫血高凝状态的研究进展

发布时间：2018-07-02 20:14

本文选题：微粒 + 溶血性贫血　；参考：《中国实验血液学杂志》2017年02期

【摘要】：微粒(MP)是各种细胞激活和凋亡时产生的微小囊泡,具有促凝促栓的作用。溶血性贫血(HA)是指红细胞遭到破坏而寿命缩短,超过骨髓造血代偿时发生的一类贫血,其中镰状细胞贫血(SCD)、地中海贫血和阵发性睡眠性血红蛋白尿(PNH)皆存在高凝状态甚至血栓高发的特点。研究表明,HA中数量及功能异常的MP能促使HA高凝状态的形成并增加血栓栓塞(TE)风险。本文主要综述近年来细胞MP在HA高凝状态中的研究进展,详述了异常MP与HA高凝状态及临床相关血栓栓塞事件(TEE)的关系,以及HA相关治疗对MP的影响、MP在部分HA动物模型中的研究及近年来热点研究的MP蛋白组学在HA中的应用。
[Abstract]:Microparticles (MP) are tiny vesicles produced by the activation and apoptosis of various cells. Hemolytic anemia (HA) is a type of anemia that occurs when the red blood cell is destroyed and the lifespan is shortened, which exceeds the hematopoietic compensation of the bone marrow. Sickle cell anemia (SCD), thalassemia and paroxysmal nocturnal hemoglobinuria (PNH) are characterized by hypercoagulability and even thrombus. It has been shown that MP with abnormal quantity and function in HA can promote the formation of hypercoagulable state of HA and increase the risk of thromboembolism (te). In this review, the recent progress in the study of cell MP in HA hypercoagulability was reviewed, and the relationship between abnormal MP and HA hypercoagulability and clinical associated thromboembolism events (tee) was described. The effect of HA related therapy on MP and the application of MP in some animal models of HA and the application of MP proteomics which has been studied in recent years.
【作者单位】：广西医科大学第一附属医院血液科;
【分类号】：R556.6

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