Hippo信号通路与心血管发育及疾病调控

发布时间：2018-07-04 15:42

本文选题：Hippo/YAP + 心脏发育　；参考：《遗传》2017年07期

【摘要】：心血管疾病已成为中国乃至全球首位死亡原因,探索心血管系统发育及调控异常的原因及相关机制可以为心血管疾病的预防和治疗提供重要的科学依据。Hippo信号通路是新近发现的在调节器官大小、细胞增殖及凋亡、干细胞命运等方面具有重要功能的一条信号通路。Hippo信号通路的不同成分参与心脏血管的发育和心血管细胞增殖、分化等功能调控,影响损伤后修复及再生等过程,该通路调节异常可引起心血管疾病,如心梗、心肌肥大、血管内膜增生、动脉硬化等。本文综述了Hippo信号通路对心血管系统发育和疾病调控的相关研究及最新进展,以期为Hippo通路在心血管疾病的发病机制及临床转化研究提供潜在的理论基础。
[Abstract]:Cardiovascular disease has become the first cause of death in China and the world. Exploring the causes and related mechanisms of abnormal cardiovascular system development and regulation may provide important scientific basis for the prevention and treatment of cardiovascular diseases. Hippo signaling pathway is recently discovered in the regulation of organ size, cell proliferation and apoptosis. The different components of the Hippo signaling pathway participate in the regulation of cardiac vascular development, cardiovascular cell proliferation and differentiation, and affect the process of repair and regeneration after injury. Abnormal regulation of the pathway may lead to cardiovascular diseases such as myocardial infarction, myocardial hypertrophy, intimal hyperplasia, arteriosclerosis, etc. This paper reviews the recent progress in the regulation of cardiovascular system development and disease by Hippo signaling pathway in order to provide a potential theoretical basis for the study of the pathogenesis and clinical transformation of Hippo pathway in cardiovascular diseases.
【作者单位】：温州医科大学基础医学院;中国科学院上海生命科学研究院生物化学与细胞生物学研究所细胞生物学国家重点实验室;
【基金】：国家自然科学基金项目(编号:81670454,81270321,31625019,91639302)资助~~
【分类号】：R54

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