血液病患者出血程度与PMP、vWF、FN的关系及临床意义
发布时间：2018-07-13 12:07
【摘要】：目的观察血小板微颗粒(PMP)、血管性血友病因子(v WF)、纤维连接蛋白(FN)在血小板减少的血液病患者中与出血程度的关系,探讨PMP、v WF、FN对出血程度预测的临床意义。方法根据WHO关于出血的分级标准,将患者分为0分组、1分组、2分组、3分组、4分组及对照组。应用流式细胞术检测患者外周血中PMP含量变化,应用ELISA法检测患者外周血中v WF、FN含量变化。结果 (1)各组PMP、v WF、FN的含量差异均有统计学意义(P0.001);(2)不同出血程度组之间出血程度越重,PMP含量越低[除1分组与2分组;3分组、4分组和对照组差异无统计学意义,其余差异有统计学意义(P0.001)]、VWF含量越高[除1分组与2分组外,其余各组之间差异有统计学意义(P0.001)]、FN含量越高[除0分组与1分组外,其余各组均差异有统计学意义(P0.001)]。结论 PMP、v WF、FN的含量对血小板减少的血液病患者出血程度的预测具有临床意义。
[Abstract]:Objective to investigate the relationship between platelet microgranule (PMP), von Willebrand factor (v WF) and fibronectin (FN) in patients with thrombocytopenia. Methods according to WHO grading standard, patients were divided into 0 groups, 1 group, 2 groups, 3 groups, 4 groups and the control group. Flow cytometry was used to detect the changes of PMP in peripheral blood, and Elisa was used to detect the changes of vWFN in peripheral blood. Results (1) there were significant differences in the content of PMPV WFF-FN in all groups (P0. 001); (2). The more severe the bleeding degree between the groups with different bleeding degree, the lower the content of PMP. [there was no significant difference between 4 groups and control groups except 1 group and 2 groups, 3 groups and 4 groups, 4 groups and the control group). The other differences were statistically significant (P0.001). The higher the content of VWF was [except for group 1 and group 2, the difference between other groups was statistically significant (P0.001)] the content of FN was higher [except group 0 and group 1, the differences among other groups were statistically significant (P0.001)]. Conclusion the content of PMPV WFFFN in patients with thrombocytopenia has clinical significance in predicting the bleeding degree of patients with thrombocytopenia.
【作者单位】： 安徽医科大学第一附属医院血液内科;安徽医科大学第一附属医院中心实验室;
【基金】：安徽省自然科学基金(编号:1308085MH157)
【分类号】：R55;R733
，
本文编号：2119316
[Abstract]:Objective to investigate the relationship between platelet microgranule (PMP), von Willebrand factor (v WF) and fibronectin (FN) in patients with thrombocytopenia. Methods according to WHO grading standard, patients were divided into 0 groups, 1 group, 2 groups, 3 groups, 4 groups and the control group. Flow cytometry was used to detect the changes of PMP in peripheral blood, and Elisa was used to detect the changes of vWFN in peripheral blood. Results (1) there were significant differences in the content of PMPV WFF-FN in all groups (P0. 001); (2). The more severe the bleeding degree between the groups with different bleeding degree, the lower the content of PMP. [there was no significant difference between 4 groups and control groups except 1 group and 2 groups, 3 groups and 4 groups, 4 groups and the control group). The other differences were statistically significant (P0.001). The higher the content of VWF was [except for group 1 and group 2, the difference between other groups was statistically significant (P0.001)] the content of FN was higher [except group 0 and group 1, the differences among other groups were statistically significant (P0.001)]. Conclusion the content of PMPV WFFFN in patients with thrombocytopenia has clinical significance in predicting the bleeding degree of patients with thrombocytopenia.
【作者单位】： 安徽医科大学第一附属医院血液内科;安徽医科大学第一附属医院中心实验室;
【基金】：安徽省自然科学基金(编号:1308085MH157)
【分类号】：R55;R733
，
本文编号：2119316
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