冠心病患者血清ADAMTS-7水平与Gensini评分的相关分析

发布时间：2018-07-18 07:23

【摘要】：目的:探讨血清ADAMTS-7在冠心病(CHD)患者中的表达水平,分析其与Gensini评分的相关性。方法:连续选取2016年4月至2017年2月在山西省人民医院心内科一病区住院的胸痛待查者389例,根据“纳入和排除标准”,入组患者共151例,分为冠脉正常且无ST-T改变者31例,CHD组120例。所有入选病例统一检测血脂、血糖、肝肾功、超敏C反应蛋白等生化指标,ELISA法测定血清ADAMTS-7的水平。按冠脉造影(CAG)结果计算Gensini积分,以Gensini评分结果将CHD组分为Ⅰ组(4~8分)37例,Ⅱ组(9~12分)23例,Ⅲ组(13~33分)31例,Ⅳ组(34分及以上)29例;以及Gensini积分为0的非CHD组共5组。应用两独立样本t检验评价CHD患者血清中ADAMTS-7水平,五组间ADAMTS-7水平比较应用方差分析(ANOVA),分析ADAMTS-7与Gensini积分的相关性应用Spearman偏相关。结果:1.CHD组的血清ADAMTS-7水平高于非CHD组,即[(71.44±27.33)ng/ml vs(36.17±14.02)ng/ml,P0.001]。2.CHD患者中Gensini积分Ⅳ组(34分及以上),Ⅲ组(13~33分),Ⅱ组(9~12分),Ⅰ组(4~8分)的血清ADAMTS-7水平均高于非CHD组的水平[(97.06±27.83)ng/ml,(75.38±25.40)ng/ml,(58.64±14.15)ng/ml,(56.01±17.76)ng/ml vs(36.17±14.02)ng/ml,P0.001]。CHD组内比较时,Ⅱ组的血清ADAMTS-7的水平略高于Ⅰ组,但无统计学差异(P0.05);剩余的Ⅳ组、Ⅲ组的血清ADAMTS-7水平均明显高于Ⅱ组、Ⅰ组,差异有统计学意义(P0.05);Ⅳ组与Ⅲ组之间的比较,差异也具有统计学意义(P0.05)。3.在调整了其他混杂因素后,ADAMTS-7水平与Gensini评分之间仍存在显著相关性(r=0.479,P0.001)。结论:CHD患者血清ADAMTS-7水平明显升高,随着Gensini积分的增高,ADAMTS-7的水平逐渐增高,ADAMTS-7水平与Gensini评分呈正相关,提示血清ADAMTS-7水平可作为评价冠脉病变程度的一个重要生化指标。
[Abstract]:Aim: to investigate the expression of serum ADAMTS-7 in patients with coronary heart disease (CHD) and to analyze the correlation between ADAMTS-7 and Gensini score. Methods: a total of 389 patients with chest pain were selected from April 2016 to February 2017 in the Department of Cardiology, Shanxi Provincial people's Hospital. According to the criteria of inclusion and exclusion, 151 patients were enrolled. The patients were divided into 31 patients with normal coronary artery and no ST-T change, 120 patients with CHD. The serum levels of ADAMTS-7 were determined by Elisa in all the patients, including blood lipids, blood glucose, liver and kidney function, and hypersensitive C-reactive protein. According to the results of coronary angiography (CAG), the Gensini score was calculated. According to the Gensini score, CHD was divided into three groups: group 鈪，

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