精准心脏病学:研究到实践

发布时间：2018-07-18 07:59

【摘要】：精准医学通过整合表型组学、多生物组学及环境社会因素,借助现代信息学技术实现个体化治疗的目标。精准心脏病学将精准医学理念与方法运用于心血管领域,采用大规模、深入型、创新性研究方法实现研究突破,促进药物研发与应用,结合临床对不同遗传背景、环境暴露的个体提出个体化风险评估、疾病诊断和干预方案,进行针对性的心血管疾病预防和诊治,最终改善患者预后并提高患者生活质量。精准心脏病学目前面临着诸多亟待解决的技术、社会和伦理障碍。随着研究与认识的深入,精准心脏病学将在攻克心血管疾病领域的诸多难关、提高心血管疾病的诊治能力过程中发挥重要作用。
[Abstract]:By integrating phenotypic, multi-biologic and environmental and social factors, precision medicine achieves the goal of individualized therapy by means of modern informatics technology. Precision cardiology applies the concept and method of precision medicine to the cardiovascular field, using large-scale, in-depth and innovative research methods to achieve research breakthroughs, promote drug development and application, and combine clinical genetic background. Individuals exposed to the environment put forward individualized risk assessment, disease diagnosis and intervention, and targeted prevention and treatment of cardiovascular disease, ultimately improve the prognosis of patients and improve the quality of life of patients. Precision cardiology is facing many technical, social and ethical obstacles to be solved. With the deepening of research and understanding, precise cardiology will play an important role in overcoming many difficulties in the field of cardiovascular disease and improving the ability of diagnosis and treatment of cardiovascular disease.
【作者单位】：中国医学科学院北京协和医院中心实验室;中国医学科学院北京协和医院心脏内科;
【基金】：国家重点研发计划项目(2016YFC0901500) 上海市出生缺陷防治重点实验室开放课题(16DZKF1007) 国家卫生计生委2016年信息化与统计项目
【分类号】：R541

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