骨髓增生异常综合征中染色体畸变类型
发布时间:2018-07-21 11:57
【摘要】:正骨髓增生异常综合征(myelodysplastic syndromes,MDS)是一类起源于骨髓造血干细胞的恶性克隆性疾病,具有明显的异质性,其特征是骨髓病态造血,细胞减少,骨髓一系或多系异型增生。临床表现主要为贫血、出血、感染等,容易发展为急性髓细胞性白血病(acute myeloid leu-kemia,AML)~[1]。MDS多见于老年人,平均发病年龄70岁。总体发病率为3~5/100 000,而70岁以上人群的发病率上升到大于20/100 000~[2]。染色体畸变在MDS的发生发展
[Abstract]:Normal myelodysplastic syndrome (myelodysplastic syndromes) is a kind of malignant clonal disease originating from bone marrow hematopoietic stem cells. It has obvious heterogeneity. It is characterized by morbid hematopoiesis, cytopenia and dysplasia of one or more lines of bone marrow. The main clinical manifestations were anemia, hemorrhage, infection, etc. It was easy to develop acute myeloid leukemia (acute myeloid leu-kemiaAML) ~ [1] .MDS was more common in the elderly, with an average age of 70 years. The overall incidence was 3 / 5 / 100, 000, while the incidence of people over 70 increased to more than 20 / 100, 000 ~ [2]. Development of chromosome aberration in MDS
【作者单位】: 武汉大学人民医院肿瘤中心;
【基金】:国家自然科学基金资助项目(编号:81670123) 湖北省自然科学基金资助项目(编号:2014CKB493)
【分类号】:R551.3
本文编号:2135448
[Abstract]:Normal myelodysplastic syndrome (myelodysplastic syndromes) is a kind of malignant clonal disease originating from bone marrow hematopoietic stem cells. It has obvious heterogeneity. It is characterized by morbid hematopoiesis, cytopenia and dysplasia of one or more lines of bone marrow. The main clinical manifestations were anemia, hemorrhage, infection, etc. It was easy to develop acute myeloid leukemia (acute myeloid leu-kemiaAML) ~ [1] .MDS was more common in the elderly, with an average age of 70 years. The overall incidence was 3 / 5 / 100, 000, while the incidence of people over 70 increased to more than 20 / 100, 000 ~ [2]. Development of chromosome aberration in MDS
【作者单位】: 武汉大学人民医院肿瘤中心;
【基金】:国家自然科学基金资助项目(编号:81670123) 湖北省自然科学基金资助项目(编号:2014CKB493)
【分类号】:R551.3
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