中国人群血清脂联素水平与冠心病相关性研究的荟萃分析

发布时间：2018-07-22 14:04

【摘要】：目的：血清脂联素水平与血脂异常、糖尿病、脑血管疾病等疾病密切相关,但关于脂联素是否与冠心病相关仍存争议。鉴于国内对于脂联素与心血管疾病关系的研究颇多,且研究结果未达成一致,因此,本次研究对中国人群血清脂联素水平与冠心病的关系进行荟萃分析。方法：通过检索国内外主要的数据库,按照纳入与排除标准获取已公开发表的关于中国人群血清脂联素水平与冠心病关系的文献,提取文献中相关数据,使用STATA 12.0统计学软件进meta分析。结果：本次荟萃分析共纳入27篇文献,总样本量为3763例,其中冠心病组为2359例,对照组为1404例。由于各研究间的存在异质性(I2=96.5%),因此通过随机效应模型进行Meta分析,结果显示中国人群的血清脂联素水平低于对照组,差异具有统计学意义[SMD=-1.88,95%CI(-2.31,-1.45), P0.05]。敏感性分析提示各项研究对总体合并效应量无明显影响,本次Meta分析结果具有较好稳健性。通过亚组分析发现在总样本量大小、冠心病组病人数、男性比例分组、NOS评分的分组时异质性有所下降,且分组后合并的结果稳定。Begg秩检验和Egger线性回归法均提示所纳入的文献有潜在的发表偏倚。结论：中国人群冠心病患者血清脂联素水平明显低于正常对照组,低血清脂联素水平与冠心病发病风险相关。由于所纳入的文献存在异质性和发表偏倚,因此中国人群脂联素与冠心病的关系仍需要进一步更多大型的、前瞻性的高质量研究进一步探讨。
[Abstract]:Objective: serum adiponectin levels are closely related to dyslipidemia, diabetes, cerebrovascular diseases and other diseases, but whether adiponectin is related to coronary heart disease is still controversial. There are many studies on the relationship between adiponectin and cardiovascular disease in China, and the results are not agreed. Therefore, the relationship between serum adiponectin level and coronary heart disease in Chinese population is analyzed in this study. Methods: the published literatures on the relationship between serum adiponectin levels and coronary heart disease in Chinese population were obtained according to the inclusion and exclusion criteria by searching the main databases at home and abroad. STATA 12.0 statistical software was used for meta analysis. Results: a total of 27 articles were included in this meta-analysis. The total sample size was 3763 cases, including 2359 cases in coronary heart disease group and 1404 cases in control group. Because of the heterogeneity among the studies (I _ 2 / 96.5%), Meta-analysis was carried out by random effect model. The results showed that the serum adiponectin level in Chinese population was lower than that in the control group, and the difference was statistically significant [SMD-1.8895 CI (-2.31 ~ 1.45), P0.05]. Sensitivity analysis showed that all studies had no significant effect on the total combined effect, and the results of this meta-analysis had good robustness. By subgroup analysis, we found that the heterogeneity of the total sample size, the number of patients in coronary heart disease group, and the proportion of males grouped by NOS score decreased. After grouping, the results were stable. Begg rank test and Egger linear regression indicated that the literature included had potential publication bias. Conclusion: the serum adiponectin level in Chinese patients with coronary heart disease is significantly lower than that in normal controls, and low serum adiponectin level is associated with the risk of coronary heart disease. Due to the heterogeneity and publication bias of the literature included, the relationship between adiponectin and coronary heart disease in Chinese population needs to be further explored.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R541.4

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