入院早期血清D-二聚体与老年急性ST段抬高性心肌梗死患者经皮冠状动脉介入术后心力衰竭的相关性
发布时间:2018-07-24 20:49
【摘要】:目的探讨入院早期血清D-二聚体(D-D)与老年急性ST段抬高性心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后心力衰竭(HF)的相关性。方法 137例STEMI患者按照入院时血清D-D水平分为D-D升高组(400μg/L,n=42)及D-D正常组(≤400μg/L,n=95),比较两组一般临床资料及PCI术后HF发生率。用Logistic回归分析血清D-D与HF发生的关系。并利用受试者工作(ROC)曲线分析血清D-D水平预测HF发生的临床价值。结果与D-D正常组比较,D-D升高组左室射血分数(LVEF)较低,血清肌钙蛋白(c Tn)I、磷酸肌酸同工酶(CK-MB)、脑钠肽前体蛋白(NT-pro BNP)、高敏C反应蛋白(hs-CRP)水平、HF发生率较高(均P0.05);Pearson相关分析及多元线性回归显示,D-D水平与反映心功能指标NT-pro BNP呈正相关,而与LVEF呈正负关(P0.05);Logistic回归分析亦显示:D-D水平(OR=1.810,95%CI:1.572~3.235,P0.05)是STEMI患者PCI术后发生HF的独立危险因素。ROC曲线分析显示,血清D-D水平预测HF发生的曲线下面积(AUC)为0.833,最佳诊断截点值为432.67μg/L,敏感性和特异性分别为87.3%和80.7%。结论血清D-D水平增高显著增加了老年STEMI患者PCI术后发生HF的风险,可能是HF发生的独立预测因素,临床医师应当密切监测入院时D-D水平变化情况,以评估患者近期预后做出临床参考。
[Abstract]:Objective to investigate the relationship between serum D-dimer (D-D) and heart failure (HF) after percutaneous coronary intervention (PCI) in elderly patients with acute St segment elevation myocardial infarction (STEMI). Methods 137 patients with STEMI were divided into two groups according to the serum D-D level at admission: D-D increased group (400 渭 g / L) and D-D normal group (鈮,
本文编号:2142614
[Abstract]:Objective to investigate the relationship between serum D-dimer (D-D) and heart failure (HF) after percutaneous coronary intervention (PCI) in elderly patients with acute St segment elevation myocardial infarction (STEMI). Methods 137 patients with STEMI were divided into two groups according to the serum D-D level at admission: D-D increased group (400 渭 g / L) and D-D normal group (鈮,
本文编号:2142614
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