血浆SCUBE1水平与新疆哈萨克族、达斡尔族、汉族原发性高血压的相关研究

发布时间：2018-07-26 15:07

【摘要】：目的:本研究通过检测新疆哈萨克族(哈族)、达斡尔族(达族)和汉族原发性高血压(EH)患者和各族血压正常人群的血浆新型血小板活化蛋白SCUBE1的水平变化,探讨其与哈族、达族、汉族EH患者间及与各族血压正常对照组血浆SCUBE1含量是否存有差异,并分析SCUBE1与血压、体质指数、血生化等指标之间的相关性。方法:采用随机数字法原则选择研究对象,选取2013年11月在新疆玛纳斯县旱卡子滩乡进行流行病学调查所获得的哈族EH组75例,相同居住地同期健康者71例作为哈族正常对照组。入选2013年12月在新疆塔城市阿西尔达斡尔民族乡进行流行病学调查所获取的达族EH组74例,正常组78例;选取2013年12月在石河子大学医学院第一附属医院体检中心所获得的汉族EH组78例,健康体检者72例为汉族正常对照组,年龄均在30-75岁。详细收集所有研究对象的一般资料;采用酶联免疫吸附法(ELISA)测定各组血浆SCUBE1水平,比较各族血浆SCUBE1水平的差异,分析血压与血浆SCUBE1水平的相关性。结果:(1)本实验研究结果显示哈族、达族、汉族EH患者血浆SCUBE1均高于其对照组,哈族、达族、汉族血浆SCUBE1水平差异具有统计学意义(P0.05)。其浓度与哈族、达族、汉族的收缩压、舒张压均呈显著正相关性(P0.01)。(2)哈族、达族、汉族三民族EH组间的比较:哈族、达族、汉族三组血浆SCUBE1活性水平依次为:哈族(96.26±13.45)ng/ml,达族(93.24±9.70)ng/ml,汉族(80.22±15.96)ng/ml,三组间差异具有统计学意义(F=42.077,P0.001);(3)哈族、达族、汉族三民族NT组间比较:哈族、达族、汉族血浆SCUBE1蛋白含量依次为:哈族(63.11±11.60)ng/ml,达族(61.18±12.30)ng/ml,汉族(57.96±13.30)ng/ml,三组间差异具有统计学意义(F=3.193,P=0.043)。结论:(1)哈族、达族、汉族三个民族高血压患者较各自对照组血浆SCUBE1水平明显升高,其中哈族高血压患者血浆SCUBE1含量高于达族高血压患者,达族高血压患者血浆SCUBE1高于汉族高血压患者。(2)哈族、达族、汉族三民族血压水平与血浆SCUBE1水平呈显著正相关,三民族EH组之间与各族对照组之间血浆SCUBE1水平存在差异,差异具有统计学意义,且可能存在民族差异,推测血压升高促进SCUBE1表达。(3)研究结果显示哈族EH组血浆SCUBE1水平与BMI、TC、LDL-C具有正相关性,达族EH组血浆SCUBE1水平与BMI、TG、TC、LDL-C具有正相关性,汉族EH组血浆SCUBE1水平与LDL-C具有正相关性,这可能与遗传因素、环境因素及生活饮食有关。
[Abstract]:Objective: to investigate the level of plasma new platelet activating protein (SCUBE1) in Kazakh, Daur and Han patients with essential hypertension (EH) and normal blood pressure (BP) in Xinjiang. Whether there were differences in plasma SCUBE1 content between EH patients and normal blood pressure control group, and to analyze the correlation between SCUBE1 and blood pressure, body mass index, blood biochemistry and so on. Methods: according to the principle of random number method, 75 cases of Han nationality EH group were selected in November 2013 from Hankatan Township, Manas County, Xinjiang, China. At the same time, 71 healthy persons in the same residence were used as the normal control group of Kazakh nationality. In December 2013, 74 cases of Dar nationality EH group and 78 cases of normal group were selected from the epidemiological investigation in Asier Daur nationality Township, Tarim City, Xinjiang. In December 2013, 78 cases of Han EH were selected from the physical examination Center of the first affiliated Hospital of Shihezi University Medical College. 72 healthy subjects were selected as the normal control group of Han nationality, aged 30-75 years. The general data of all the subjects were collected in detail, the plasma SCUBE1 levels were measured by Elisa (ELISA), the differences of plasma SCUBE1 levels were compared, and the correlation between blood pressure and plasma SCUBE1 levels was analyzed. Results: (1) the results of this study showed that the plasma SCUBE1 levels in the patients with EH were significantly higher than those in the control group (P0.05). The concentrations were positively correlated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) of Kazakh, Da and Han nationality (P0.01). (2). The levels of plasma SCUBE1 activity in Han nationality were (96.26 卤13.45) ng / ml, (93.24 卤9.70) ng / ml and (80.22 卤15.96) ng / ml, respectively. The difference among the three groups was statistically significant (FF42.077nP0.001); (3). The levels of plasma SCUBE1 protein in Han nationality were (63.11 卤11.60) ng / ml, (61.18 卤12.30) ng / ml and (57.96 卤13.30) ng / ml, respectively. Conclusion: (1) the plasma SCUBE1 levels of the three ethnic groups were significantly higher than that of the control group. The plasma SCUBE1 level in the patients with hypertension was higher than that in the controls. (2) there was a significant positive correlation between blood pressure level and plasma SCUBE1 level in Han nationality, Kazakh nationality, Da nationality and Han nationality, and there was significant difference in plasma SCUBE1 level between the three nationality EH group and the control group. The difference was statistically significant, and there might be ethnic differences. (3) the results showed that the plasma SCUBE1 level was positively correlated with BMITCU LDL-C in Kazakh EH group, and the plasma SCUBE1 level was positively correlated with BMI-TGG TCU LDL-C in Da-nationality EH group, the results showed that there was a positive correlation between the plasma SCUBE1 level and BMI-TGG TCU LDL-C in the EH group. There was a positive correlation between plasma SCUBE1 level and LDL-C in EH group of Han nationality, which may be related to genetic factors, environmental factors and diet.
【学位授予单位】：石河子大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R544.11

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