不稳定心绞痛患者肺炎衣原体抗体IgG和IgM表达状况及感染相关性分析

发布时间：2018-07-29 19:05

【摘要】：目的研究不稳定心绞痛患者肺炎衣原体抗体IgG和IgM表达,分析感染因素。方法选取2014年8月-2015年8月医院接诊40例不稳定心绞痛患者为观察组,另选取同期健康体检者40名为对照组,检测两组受试者TNF-α、CRP、tPA、PAI-1及CpnIgG、CpnIgM表达,观察两组相关资料比较,TNF-α、CRP、tPA、PAI-1及Cpn抗体检测结果,肺炎衣原体抗体IgG与各监测指标水平比较。结果两组tPA水平无明显差异,观察组TNF-α(2.84±0.26)μg/L、CRP(6.82±1.10)mg/L、PAI-1(0.82±0.12)AU/ml均大于对照组(0.60±0.28)μg/L、(2.47±0.70)mg/L、(0.45±0.14)AU/ml,差异有统计学意义(P0.05);两组Cpn-IgM阳性率无明显差异,Cpn-IgG阳性率差异有统计学意义(P0.05),两组HDL-C水平无明显差异;阳性组TC、TG、LDL-C、PAI-1、CRP、TNF-α(4.92±0.89、1.87±0.59、2.56±0.68)mmol/L、(0.79±0.24)AU/ml、(5.26±1.30)mg/L、(2.19±0.68)μg/L均大于阴性组(4.22±0.75、1.18±0.31、2.19±0.56)mmol/L、(0.38±0.11)AU/ml、(2.70±0.86)mg/L、(1.06±0.34)μg/L(P0.05),tPA活性(0.43±0.05)IU/ml小于阴性组(0.52±0.07)IU/ml,差异有统计学意义(P0.05)。结论肺炎衣原体抗体IgG与不稳定心绞痛有密切的关系,会促进炎症因子的释放,诱导CRP、TNF-α产生,干扰血浆脂质代谢,从而导致患者不稳定心绞痛病发。
[Abstract]:Objective to study the expression of chlamydia pneumoniae antibody IgG and IgM in patients with unstable angina pectoris. Methods from August 2014 to August 2015, 40 patients with unstable angina pectoris were selected as observation group and 40 healthy persons as control group. The expression of TNF- 伪 -CRPtPA-PAI-1 and CpnIgGtPAI-1 and CpnIgGfCpnIgM were detected in both groups. The results of TNF- 伪 CRPPAI-1 and Cpn antibodies were compared between the two groups, and the levels of chlamydia pneumoniae antibody IgG were compared with each other. Results there was no significant difference in the level of tPA between the two groups. TNF- 伪 (2.84 卤0.26) 渭 g / L CRP (6.82 卤1.10) mg / L PAI-1 (0.82 卤0.12) AU/ml in the observation group was significantly higher than that in the control group (0.60 卤0.28) 渭 g / L, (2.47 卤0.70) mg / L, (0.45 卤0.14) AUP / ml (P0.05), and there was no significant difference in the positive rate of Cpn-IgM between the two groups (P0.05). 闃虫，

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