同种和不同种药物洗脱支架治疗药物支架内再狭窄有效性的系统评价

发布时间：2018-07-31 09:58

【摘要】：目的：评价同种药物洗脱支架和不同种药物洗脱支架治疗冠状动脉药物支架内再狭窄的有效性。方法：计算机检索检索Pubmed数据库、OVID数据库、Embase数据库、Cochrane图书馆、Google学术搜索、万方数据库、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普数据库(VIP),检索文章时间为各大数据库建库至2014年10月。对符合纳入标准的文献用RevMan5.2软件,系统评价不同种药物洗脱支架治疗药物支架内狭窄的靶病变血运重建率或靶血管血运重建率,次要疗效指标包括：主要不良心脏事件、病死率、心肌梗死发生率。收集同种和不同种药物洗脱支架治疗冠状动脉药物支架内再狭窄的相关研究,共纳入10个临床研究,1680名患者,使用RevMan 5.2软件进行系统评价。结果：在治疗冠状动脉药物支架内再狭窄时,不同药物支架组的靶病变或靶血管血运重建率低于同种药物支架组,二者之间有统计学意义[OR=0.73,95%CI(0.55,0.96),P=0.02];不同药物支架组的主要不良心脏事件发生率低于同种药物支架组,两组间存在统计学意义[OR=0.72,95%CI(0.54,0.96),P=0.03]。两组间的病死率及心肌梗死发生率无显著统计学差异[病死率的比较：OR=1.03,95%CI(0.49,2.16),P=0.95;心肌梗死发生率的比较：OR=0.59,95%CI(0.24,1.41),P=0.23]。结论：对于药物洗脱支架内再狭窄患者,再次植入不同药物支架比植入相同支架更获益。
[Abstract]:Aim: to evaluate the efficacy of drug-eluting stents and drug-eluting stents in the treatment of restenosis in coronary artery stents. Methods: Pubmed database and Embase database were searched by computer. Full text Database of Chinese academic Journals (CNKI), China Biomedical Literature Database (CBM), Wiper Database (VIP), retrieval time for each database was built up to October 2014. RevMan5.2 software was used to systematically evaluate the rate of revascularization or revascularization of target lesions in the treatment of stenosis in stents with different drug eluting stents. The secondary therapeutic effects included major adverse cardiac events. Mortality, incidence of myocardial infarction. A total of 1680 patients with coronary artery restenosis were enrolled in 10 clinical studies. The patients were systematically evaluated with RevMan 5.2 software in the treatment of intracoronary restenosis with the same or different drug eluting stents. Results: in the treatment of coronary stent restenosis, the target lesion or target vessel revascularization rate in different drug stent groups was lower than that in the same drug stent group. The incidence of major adverse cardiac events in different drug stent groups was lower than that in the same drug stent group, and there was statistical significance between the two groups [OR0.72 卤95CI (0.540.96) P 0.03]. There was no significant difference in mortality and incidence of myocardial infarction between the two groups. Conclusion: for patients with drug-eluting stent restenosis, reimplantation of different stents is more beneficial than implantation of the same stent.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R541.4
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本文编号：2155227