动态动脉硬化指数与冠心病相关性的Meta分析

发布时间：2018-08-01 11:53

【摘要】：目的:综合评价动态动脉硬化指数与冠心病的相关性,为冠心病的预防和诊治提供循证医学证据。方法:检索相关期刊论文、万方数据库、维普中文科技期刊全文数据库、中国生物医学文献数据库、Pub Med、Embase、the Cochrane Library等数据库,收集有关“动态动脉硬化指数”与“冠状动脉性心脏病”的相关文献,提取相关数据,采用Review Manager 5.3统计学软件进行Meta分析。结果:共纳入17篇文献,包括4912例研究对象。Meta分析结果显示:冠心病组动态动脉硬化指数高于正常对照组,差异有统计学意义[MD=0.05,P0.00001]。失安全系数Nfs0.05为194,提示Meta分析结果稳定可靠。进一步根据病变支数分组行Meta分析,结果显示:除单支病变组与正常对照组差异无统计学意义[MD=0.01,P0.05],其余各组间差异均存在统计学意义(MD分别为0.06、0.09、0.05、0.08、0.03,P值均小于0.05)。结论:动态动脉硬化指数与冠心病有相关性,且随着冠状动脉病变程度的加重,动态动脉硬化指数与冠心病的相关性越强。
[Abstract]:Objective: to evaluate the correlation between dynamic arteriosclerosis index and coronary heart disease and to provide evidence for prevention and treatment of coronary heart disease. Methods: the databases of Chinese periodical full-text database, Wanfang database, Weipu Chinese sci-tech journal full-text database, Chinese biomedical literature database Pub Medbase and the Cochrane Library were searched. To collect the relevant literature about dynamic arteriosclerosis index and coronary heart disease, extract the relevant data, and use Review Manager 5.3 statistical software to carry out Meta analysis. Results: a total of 17 articles were included, including 4912 subjects. Meta-analysis results showed that the dynamic arteriosclerosis index of coronary heart disease group was higher than that of normal control group, and the difference was statistically significant [MDD 0.05 + P 0.00001]. The unsafe factor (Nfs0.05) is 194.This indicates that the results of Meta analysis are stable and reliable. Furthermore, Meta analysis was performed according to the number of lesion branches. The results showed that there was no significant difference between the single vessel lesion group and the normal control group (P < 0. 05), but there was significant difference between the other groups (MD was 0. 06 卤0. 09%, 0. 05%, 0. 08% P < 0. 05). Conclusion: dynamic arteriosclerosis index is correlated with coronary artery disease, and the correlation between dynamic arteriosclerosis index and coronary heart disease is stronger with the severity of coronary artery disease.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4

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