高血压中枢发病机制的研究进展

发布时间：2018-08-07 11:13

【摘要】：高血压是我国人群脑卒中及冠心病发病的首位危险因素,严重危害人群健康。目前,我国高血压患者已超过2.7亿,并以每年1 000万人的速度递增,如何提高对高血压的预防和治疗水平已成为迫切需要解决的重大医学和社会问题。以往对于高血压的研究主要集中于外周。近来研究表明,中枢调控在高血压的发生发展中具有重要作用。其中下丘脑室旁核(hypothalamic paraventricular nucleus,PVN)在维持心血管活动中起着关键作用,可直接支配交感神经节前神经元,参与外周交感神经活动的调节,并与高血压的发生发展密切相关。近年来研究表明,室旁核中炎性细胞因子(proinflammatory cytokines,PIC)、活性氧簇(reactive oxygen species,ROS)、肾素-血管紧张素系统(reninangiotensin system,RAS)、神经递质(neurotransmitter,NT)及核因子κB(nuclear factorκB,NF-κB)等神经激素参与高血压的病理生理过程,但室旁核中这些神经激素如何激活、相互间的作用以及对高血压的调控机制尚不清楚。因此,探明下丘脑室旁核神经激素兴奋对高血压的影响是本课题的研究重点。本研究将为高血压的中枢机制研究补充新内容。
[Abstract]:Hypertension is the first risk factor of stroke and coronary heart disease in Chinese population. At present, there are more than 270 million patients with hypertension in China and increasing at the rate of 10 million people per year. How to improve the level of prevention and treatment of hypertension has become a major medical and social problem that needs to be solved urgently. Previous studies of hypertension have focused on peripheral blood pressure. Recent studies have shown that central regulation plays an important role in the occurrence and development of hypertension. The hypothalamic paraventricular nucleus (hypothalamic paraventricular) plays a key role in the maintenance of cardiovascular activity. It can directly innervate the sympathetic preganglionic neurons, participate in the regulation of peripheral sympathetic activity, and be closely related to the occurrence and development of hypertension. Recent studies have shown that neurohormones such as proinflammatory cytokines, reactive oxygen species (reactive oxygen speciesRos, reninangiotensin system Ras, neurotransmitter NT and nuclear factor 魏 B (nuclear factor 魏 B NF- 魏 B are involved in the pathophysiological process of hypertension. However, it is unclear how these neurohormones activate, interact and regulate hypertension in the paraventricular nucleus. Therefore, it is important to investigate the effect of hypothalamic paraventricular nucleus stimulation on hypertension. This study will complement the central mechanism of hypertension.
【作者单位】：西安交通大学医学部基础医学院;
【基金】：国家自然科学基金重大研究计划项目(No.91439120);国家自然科学基金面上项目(No.81370356;81170248;81070199)~~
【分类号】：R544.1

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