乌头赤石脂汤对老年缺血性心肌病伴心力衰竭患者血清TNF-α,BNP及Hcy水平的影响

发布时间：2018-08-07 14:40

【摘要】：目的:探讨乌头赤石脂汤对老年缺血性心肌病伴心力衰竭患者血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α),B型钠尿肽(B-type natriuretic peptide,BNP)及同型半胱氨酸(homocysteine,Hcy)水平的影响。方法:取郑州市中医院治疗的缺血性心肌病心力衰竭老年患者94例,按随机数字表法分为治疗组和对照组,对照组(47例)予以基础治疗,治疗组(47例)在基础治疗上联用乌头赤石脂汤治疗,观察并记录心室重构及心功能、血清指标、生活质量等指标,同时观察临床疗效及不良反应。结果:治疗后对照组治疗有效率(74.47%)低于治疗组(91.49%)(P0.05);与治疗前比较,两组治疗后心室重构及心功能、血清指标、生活质量均发生变化,治疗组治疗后左心室舒张末内径(left ventricular end diastolic diameter,LVEDD),左室收缩末期内径(left ventricular end systolic diameter,LVESD)指标低于对照组(P0.05),左心室射血分数(left ventricular ejection fraction,LVEF),每分钟输出量(output per minute,CO)指标高于对照组(P0.05),治疗组治疗后血清BNP,肌钙蛋白I(Troponin I,c Tn I),高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP),TNF-α,Hcy水平低于对照组(P0.05),治疗组治疗后生活质量改善程度优于对照组(P0.05);两组治疗期间无严重不良反应发生。结论:采用乌头赤石脂汤对老年缺血性心肌病伴心力衰竭疗效确切,能降低血清TNF-α,BNP及Hcy水平,提高生活质量。
[Abstract]:Objective: to investigate the effect of aconite Chishi decoction on serum tumor necrosis factor 伪 (tumor necrosis factor- 伪 (TNF- 伪) B natriuretic peptide (B-type natriuretic) and homocysteine (homocysteine) in elderly patients with ischemic cardiomyopathy complicated with heart failure. Methods: Ninety-four elderly patients with heart failure of ischemic cardiomyopathy treated by traditional Chinese Medicine Hospital of Zhengzhou City were divided into treatment group and control group according to random digital table method. The control group (47 cases) was treated with basic treatment. The treatment group (47 cases) was treated with Aconitum Chishi decoction on basic treatment. Ventricular remodeling, cardiac function, serum index, quality of life and other indexes were observed and recorded. The clinical efficacy and adverse reactions were also observed. Results: the effective rate of treatment in the control group (74.47%) was lower than that in the treatment group (91.49%) (P0.05). Left ventricular end-diastolic diameter (left ventricular end diastolic), left ventricular end-systolic diameter (left ventricular end systolic diameterus LVESD), left ventricular ejection fraction (left ventricular ejection fractionation) and (output per minute CO (P 0.05) were significantly lower in the treatment group than those in the control group (P 0.05). The left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (left ventricular ejection fractionation) were significantly higher in the treatment group than those in the control group (P0.05). After treatment, the levels of serum BNPs, I (Troponin IPC Tn I), Gao Min C-reactive protein (high-sensitivity C-reactive protein hs-CRP) in the treatment group were lower than those in the control group (P0.05), and the improvement of the quality of life in the treatment group was better than that in the control group (P0.05). Conclusion: Aconitou Chishi decoction is effective in the treatment of elderly ischemic cardiomyopathy with heart failure. It can reduce serum TNF- 伪 -BNP and Hcy levels and improve quality of life.
【作者单位】：郑州市中医院;河南省中医院;
【基金】：河南省教育厅教育科学“十二五”规划课题项目(2013-JKGHA-0004)
【分类号】：R541.6;R542.2

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