原发性高血压患者尿NGAL水平检测对肾功能损害的早期诊断价值

发布时间：2018-08-13 14:25

【摘要】：目的探讨尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)检测对原发性高血压患者肾功能损害的早期诊断价值。方法选取原发性高血压患者79例(高血压组)和体检健康人群26例(对照组),采用电化学发光仪检测两组血清肌酐(Scr),并以Cockroff-Gault公式计算肾小球滤过率(eGFR)。采用酶联免疫双抗体夹心法测定两组尿NGAL水平。高血压组留取24 h尿液并以二甲苯防腐,测量24 h尿蛋白排泄率(UAER),并根据24 h UAER分为正常蛋白尿组(UAER30 mg/24 h)26例、微量蛋白尿组(UAER30~300 mg/24 h)27例、临床蛋白尿组(UAER300 mg/24 h)26例。结果与对照组相比,高血压组尿NGAL、Scr上升,eGFR下降(P均0.05)。正常蛋白尿组、微量蛋白尿组、临床蛋白尿组三组间尿NGAL、Scr及eGFR比较差异有统计学意义(P均0.05)。两两比较,临床蛋白尿组、微量蛋白尿组尿NGAL及Scr水平高于正常蛋白尿组,eGFR低于正常蛋白尿组(P均0.05);临床蛋白尿组尿NGAL水平高于微量蛋白尿组(P0.05);临床蛋白尿组Scr水平、eGFR与微量蛋白尿组比较差异无统计学意义(P均0.05)。Pearson相关性分析显示,高血压患者尿NGAL水平与Scr水平呈正相关(r=0.595,P0.05),与eGFR呈负相关(r=-0.4812,P0.05)。结论原发性高血压患者尿NGAL水平升高,且其水平变化与肾功能损害严重程度一致;尿NGAL水平可作为判断原发性高血压患者早期肾功能损害的可靠指标。
[Abstract]:Objective to investigate the early diagnostic value of urinary neutrophil gelatinase-associated lipid carrier protein (NGAL) in the diagnosis of renal dysfunction in patients with essential hypertension. Methods 79 patients with essential hypertension (hypertension group) and 26 healthy people (control group) were selected. Serum creatinine (Scr), was detected by electrochemiluminescence (ECL) and glomerular filtration rate (eGFR).) was calculated by Cockroff-Gault formula. The level of urinary NGAL was measured by enzyme-linked immunosorbent assay (Elisa). 24 h urine was taken from hypertensive group and preserved with xylene. The 24 h urinary protein excretion rate (UAER),) was measured and divided into normal proteinuria group (UAER30 mg/24 h) (26 cases), microalbuminuria (UAER30~300 mg/24 h) group (27 cases) and clinical proteinuria group (UAER300 mg/24 h) 26 cases according to 24 h UAER. Results compared with control group, urinary NGALSCR increased and eGFR decreased in hypertension group (P 0.05). There were significant differences in urinary NGALL SCR and eGFR among normal proteinuria group, microalbuminuria group and clinical proteinuria group (P 0.05). Two to two comparisons, clinical proteinuria group, The levels of urinary NGAL and Scr in microalbuminuria group were higher than those in normal proteinuria group (all P 0.05), the urinary NGAL level in clinical proteinuria group was higher than that in microalbuminuria group (P0.05), the Scr level in clinical proteinuria group was higher than that in microalbuminuria group (P0.05), and the Scr level in clinical proteinuria group was higher than that in microalbuminuria group. There was no significant difference (P 0.05). Pearson correlation analysis showed that, There was a positive correlation between urinary NGAL level and Scr level in hypertensive patients (P 0.05), and a negative correlation between urinary NGAL level and eGFR level (r = 0.4812 P 0.05). Conclusion the level of urinary NGAL in patients with essential hypertension is higher than that in patients with essential hypertension, and the change of urinary NGAL level is consistent with the severity of renal function damage, and the level of urinary NGAL can be used as a reliable index to judge the early renal function damage in patients with essential hypertension.
【作者单位】：淄博市第一医院;
【分类号】：R544.11

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