替格瑞洛辅助急诊PCI治疗STEMI对患者心室重构影响情况分析

发布时间：2018-08-29 16:59

【摘要】：目的探讨ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)行急诊经皮冠脉介入术(percutaneous coronary intervention,PCI)患者加用替格瑞洛治疗的临床效果及对患者心室重构的影响。方法选取我院急诊PCI手术治疗的STEMI患者120例(2014年1月至2016年8月)进行回顾性分析,患者均急诊PCI手术,根据治疗药物分为两组,60例患者术前及术后均给予替格瑞洛(替格瑞洛组)、60例患者术前及术后均给予氯吡格雷(氯吡格雷组),对比两组患者术后心室重构指标、心电图等指标。结果术后12周,替格瑞洛组LVEDd(49.1±5.4)mm、LVESD(40.6±4.6)mm、LVMI(112.8±11.0)g/m~2、LVMW(140.7±18.5)g低于氯吡格雷组患者LVEDd(53.1±4.6)mm、LVESD(43.9±4.7)mm、LVMI(118.2±9.4)g/m2、LVMW(153.0±21.3)g(t=4.638、t=3.887、t=2.891、t=2.198,P均0.05),两组患者的LVEF值差异无统计学意义(t=1.064,P0.05);术后12周,替格瑞洛组Tp-e(114.2±12.7)ms、Tp-e/QTc(0.20±0.05)低于氯吡格雷组患者Tp-e(120.6±13.9)ms、Tp-e/QTc(0.25±0.07)(t=2.633、t=4.502,P0.05);替格瑞洛组的不良心血管事件发生率6.67%与氯吡格雷组的13.33%比较,差异无统计学意义(χ2=1.481,P0.05)。讨论STEMI行PCI患者加用替格瑞洛治疗能有效减轻心室重构,改善心电图指标。
[Abstract]:Objective to investigate the effect of tigrilol on ventricular remodeling in patients with ST segment elevation myocardial infarction (ST-segment elevation myocardial infarction,STEMI) undergoing emergency percutaneous coronary intervention (percutaneous coronary intervention,PCI). Methods one hundred and twenty patients with STEMI underwent emergency PCI operation in our hospital from January 2014 to August 2016 were retrospectively analyzed. According to the therapeutic drugs, 60 patients were divided into two groups: before and after operation, 60 patients were given clopidogrel (clopidogrel group) before and after operation, and the indexes of ventricular remodeling and electrocardiogram were compared. 缁撴灉鏈�鍚�12鍛，

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