不同形状血管中医用支架扩张力学行为的研究进展
发布时间：2018-09-03 18:25
【摘要】：血管支架介入术由于其微创性和高效性已经成为目前治疗由血管狭窄所引发的冠心病的主要治疗手段,但支架内再狭窄却是影响支架远期效果的最大障碍,严重制约了其实际疗效。首先从支架内再狭窄的形成机制出发,从固体力学角度回顾力学环境对再狭窄的影响,并主要阐述近年来支架在圆直、锥形、分叉、弯曲4种不同形状血管内扩张的研究进展,特别是从支架扩张对血管应力及血管形状的改变与再狭窄的相关关系方面进行综述。最后,针对不同血管形状对支架扩张的影响,提出一个旨在提高支架扩张性能及减少支架内再狭窄的血管支架多目标优化设计方法。
[Abstract]:Because of its minimally invasive and high efficiency, stent intervention has become the main treatment for coronary heart disease caused by vascular stenosis, but stent restenosis is the biggest obstacle to the long-term effect of stent. It seriously restricts its actual curative effect. Starting from the formation mechanism of in-stent restenosis, this paper reviews the influence of mechanical environment on restenosis from the point of view of solid mechanics, and mainly describes the research progress of stent dilatation in four different shapes in recent years: straight, conical, bifurcation and bending. In particular, the relationship between stent dilation and vascular stress, shape and restenosis is reviewed. Finally, aiming at the influence of different vascular shapes on stent dilatation, a multi-objective optimization design method is proposed to improve stent dilatation performance and reduce restenosis in stent.
【作者单位】： 江苏大学机械工程学院;
【基金】：国家自然科学基金项目(51305171) 江苏省自然科学基金项目(BK20130525)
【分类号】：R54
[Abstract]:Because of its minimally invasive and high efficiency, stent intervention has become the main treatment for coronary heart disease caused by vascular stenosis, but stent restenosis is the biggest obstacle to the long-term effect of stent. It seriously restricts its actual curative effect. Starting from the formation mechanism of in-stent restenosis, this paper reviews the influence of mechanical environment on restenosis from the point of view of solid mechanics, and mainly describes the research progress of stent dilatation in four different shapes in recent years: straight, conical, bifurcation and bending. In particular, the relationship between stent dilation and vascular stress, shape and restenosis is reviewed. Finally, aiming at the influence of different vascular shapes on stent dilatation, a multi-objective optimization design method is proposed to improve stent dilatation performance and reduce restenosis in stent.
【作者单位】： 江苏大学机械工程学院;
【基金】：国家自然科学基金项目(51305171) 江苏省自然科学基金项目(BK20130525)
【分类号】：R54
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