miRNA-1在高血压左心室肥厚诊断中的价值

发布时间：2018-09-16 21:52

【摘要】：目的:探讨miRNA-1在高血压左心室肥厚诊断中的价值,为获取心脏疾病相关信息提供新的方法和途径。方法:收集210例入住我院心内科的患者,其中70例为高血压合并左室肥厚组(HBP-LVH组)、70例为高血压不合并左室肥厚组(HBP-NLVH组),以及70例门诊随机选择健康体检者为对照组,所有入选患者完善一般临床资料、常规检查,心脏超声检查测定室间隔厚度(IVSd)与左室后壁厚度(LVPWd)。收集血浆后用qRTPCR检测miRNA-1的表达。结果:与对照组和HBP-NLVH组比较,HBP组的IVSd、LVPWd、miRNA-1显著升高,差异具有统计学意义(均P0.05)。血浆miRNA-1在LVH诊断中的敏感度和特异度分别为94.6%和89.8%。miRNA-1水平与IVSd和LVPWd均表现为正相关,相关系数R分别为0.64和0.66。结论:miRNA-1在高血压左心室肥厚患者的外周循环血浆中特异性高表达,且与左心室肥厚呈正相关,诊断左心室肥厚有很好的敏感度和特异度。
[Abstract]:Objective: to explore the value of miRNA-1 in the diagnosis of hypertensive left ventricular hypertrophy (LVH) and to provide a new method and approach for obtaining information about heart disease. Methods: a total of 210 patients admitted to our hospital were collected, 70 of whom were hypertension with left ventricular hypertrophy (HBP-LVH), 70 were hypertension without left ventricular hypertrophy (HBP-NLVH), and 70 were randomly selected as control group. All patients were selected to complete general clinical data, routine examination, echocardiography to determine the thickness of ventricular septal thickness (IVSd) and left ventricular posterior wall thickness (LVPWd). The expression of miRNA-1 was detected by qRTPCR after plasma collection. Results: compared with control group and HBP-NLVH group, IVSd,LVPWd,miRNA-1 in HBP group was significantly higher than that in control group and HBP-NLVH group (P0.05). The sensitivity and specificity of plasma miRNA-1 in the diagnosis of LVH were 94.6%, and the level of 89.8%.miRNA-1 was positively correlated with IVSd and LVPWd, the correlation coefficient R was 0.64 and 0.66, respectively. Conclusion the specific expression of microRNA-1 in peripheral circulation plasma of hypertensive patients with left ventricular hypertrophy is high, and it is positively correlated with left ventricular hypertrophy. The diagnosis of left ventricular hypertrophy has good sensitivity and specificity.
【作者单位】：海口市人民医院心内科;
【分类号】：R544.1

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