颈动脉粥样硬化与血管危险因素的相关性

发布时间：2018-09-17 08:02

【摘要】：目的探讨颈动脉粥样硬化(CAS)与各血管危险因素的相关性。方法选择年龄40~85岁的364例病人,分为CAS组及对照组,每例患者均记录有无高血压史、糖尿病史、年龄、性别,测量血压、空腹血糖(FPG)、甘油三酯(TC)、总胆固醇(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、体重指数(BMI)等。其中CAS 209例,通过测量颈动脉内中膜厚度(IMT)、收缩期峰值血流速度(PSV)、斑块回声及有无狭窄来判定CAS病变的程度,CAS再分为内中膜增厚组、软斑块组、混合斑块组、硬斑块组及狭窄组,比较各组间的高血压病史、收缩压(SBP)、舒张压(DBP)、糖尿病病史、TC、TG、HDL-C、LDL-C、UA、BMI、年龄等。结果单因素分析显示,CAS组与对照组间高血压病史、SBP、DBP、糖尿病病史、血UA、年龄、BMI差异有统计学意义(P0.05)。多因素Logistic回归分析显示,年龄、高血压及血UA与CAS密切相关(P0.05)。CAS各组间高血压病史、SBP、糖尿病病史、LDL-C、UA、年龄差异有统计学意义(P0.05);性别、BMI、DBP、TC、TG、HDL-C比较无统计学意义(P0.05)。结论 CAS与传统危险因素密切相关,新的危险因素可以成为评价动脉粥样硬化的可靠指标。
[Abstract]:Objective to investigate the relationship between carotid atherosclerosis (CAS) and vascular risk factors. Methods 364 patients aged 40 to 85 years were divided into two groups: CAS group and control group. The history of hypertension, diabetes, age, sex and blood pressure were recorded in each patient. Fasting blood glucose (FPG), triglyceride (TC), total cholesterol (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), uric acid (UA), body mass index (BMI), etc. The degree of CAS lesions was determined by measuring the peak systolic velocity of carotid intima-media thickness (IMT),) and the degree of CAS stenosis. The patients were divided into three groups: intima-media thickening group, soft plaque group, and mixed plaque group. The history of hypertension, systolic blood pressure (SBP),) and diastolic blood pressure (DBP),) were compared between the two groups. Results the univariate analysis showed that there were significant differences in hypertension history, diabetes history and UA, age between CAS group and control group (P0.05). Multivariate Logistic regression analysis showed that age, hypertension and blood UA were closely correlated with CAS (P0.05). Conclusion CAS is closely related to traditional risk factors, and new risk factors can be used as a reliable index to evaluate atherosclerosis.
【作者单位】：山东大学齐鲁医院;
【分类号】：R543.4

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